ArticleEuropean radiology2014
Dual-phase dual-energy CT in patients with lung cancer: assessment of the additional value of iodine quantification in lymph node therapy response.
Article in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 79 citations in OpenAlex.
- Evaluation of induction chemotherapy response using multiphasic dual-energy CT in nasopharyngeal carcinoma.European radiology · 2025Article
- Dual-energy CT iodine concentration as a biomarker for immunotherapy treatment response in metastatic melanoma and renal cell carcinoma patients.European radiology · 2025Article
- The diagnosis value of dual-energy computed tomography (DECT) multi-parameter imaging in lung adenocarcinoma and squamous cell carcinoma.BMC pulmonary medicine · 2024Article
- A paradigm shift in oncology imaging: a prospective cross-sectional study to assess low-dose deep learning image reconstruction versus standard-dose iterative reconstruction for comprehensive lesion detection in dual-energy computed tomography.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Dual-energy computed tomography for evaluating nodal staging in lung adenocarcinoma: correlation with surgical pathology.Japanese journal of radiology · 2024Article
- Predicting epidermal growth factor receptor mutations in non-small cell lung cancer through dual-layer spectral CT: a prospective study.Insights into imaging · 2024Article
- Dual-Energy CT in Oncologic Imaging.Tomography (Ann Arbor, Mich.) · 2024Review
- Added value of arterial enhancement fraction derived from dual-energy computed tomography for preoperative diagnosis of cervical lymph node metastasis in papillary thyroid cancer: initial results.European radiology · 2024Article
- Dual-Layer Spectral Detector Computed Tomography Quantitative Parameters: A Potential Tool for Lymph Node Activity Determination in Lymphoma Patients.Diagnostics (Basel, Switzerland) · 2024Article
- Novel biomarkers based on dual-energy computed tomography for risk stratification of very early distant metastasis in colorectal cancer after surgery.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Thoracic Diseases: Technique and Applications of Dual-Energy CT.Diagnostics (Basel, Switzerland) · 2023Review
- Advances for Pulmonary Functional Imaging: Dual-Energy Computed Tomography for Pulmonary Functional Imaging.Diagnostics (Basel, Switzerland) · 2023Review
- State of the Art: Lung Cancer Staging Using Updated Imaging Modalities.Bioengineering (Basel, Switzerland) · 2022Review
- Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors.Scientific reports · 2022Article
- Use quantitative parameters in spectral computed tomography for the differential diagnosis of metastatic mediastinal lymph nodes in lung cancer patients.Journal of thoracic disease · 2021Article
- Added value of spectral parameters for the assessment of lymph node metastasis of lung cancer with dual-layer spectral detector computed tomography.Quantitative imaging in medicine and surgery · 2021Article
- Dual-Energy CT Material Decomposition in Pediatric Thoracic Oncology.Radiology. Imaging cancer · 2021Review
- Comparison of Spectral and Perfusion Computed Tomography Imaging in the Differential Diagnosis of Peripheral Lung Cancer and Focal Organizing Pneumonia.Frontiers in oncology · 2021Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the potential contribution of iodine uptake calculation from dual-phase dual-energy CT (DE-CT) for lymph node staging and therapy response monitoring in lung cancer patients.
methodsRetrospective analysis of 27 patients with non-small cell lung carcinoma (NSCLC), who underwent dual-phase DE-CT before and after chemotherapy, was performed. Iodine uptake (mg/mL) and total iodine uptake (mg) were calculated using prototype software in the early (arterial) and late (venous) post-contrast circulatory phase in 110 mediastinal lymph nodes. The arterial enhancement fraction (AEF) was calculated and compared with lymph node size and response to chemotherapy.
resultsA significant difference of AEF was observed between enlarged (90.4%; 32.3-238.5%) and non-enlarged (72.7%; -37.5-237.5%) lymph nodes (p = 0.044) before treatment onset. A significantly different change of AEF in responding (decrease of 26.3%; p = 0.022) and non-responding (increase of 43.0%; p = 0.031) lymph nodes was demonstrated. A higher value of AEF before treatment was observed in lymph nodes with subsequent favourable response (88.6% vs. 77.7%; p = 0.122), but this difference did not reach statistical significance.
conclusionsThe dual-phase DE-CT examination with quantification of ratio of early and late post-contrast iodine uptake is a feasible and promising method for the functional evaluation of mediastinal lymph nodes including therapy response assessment. KEY POINTS: • Dual-phase DE-CT is beneficial for mediastinal lymph node assessment in NSCLC. • Arterial to venous iodine uptake ratio was higher in enlarged lymph nodes. • Change of arterial enhancement fraction correlated to therapy response.
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