ReviewMolecular brain2014
Genes and signaling pathways involved in memory enhancement in mutant mice.
Review in Molecular brain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- A missense mutation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- CTRP4 ablation impairs associative learning and memory.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Assessment of Cognitive Phenotyping in Inbred, Genetically Modified Mice, and Transgenic Mouse Models of Alzheimer's Disease.Experimental neurobiology · 2019Review
- Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size.Neuron · 2019Article
- Molecular Mechanisms of the Memory Trace.Trends in neurosciences · 2019Review
- Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice.Frontiers in systems neuroscience · 2018Article
- Restoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition.Molecular brain · 2017Article
- PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory.Scientific reports · 2017Article
- SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in the Hippocampus.Frontiers in molecular neuroscience · 2017Article
- ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation.Molecular brain · 2016Article
- The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Impaired learning and memory in CD38 null mutant mice.Molecular brain · 2016Article
- Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, with Upregulation of Multiple Synaptic Proteins.Frontiers in molecular neuroscience · 2016Article
- Analysis of phosphoinositide-binding properties and subcellular localization of GFP-fusion proteins.Lipids · 2015Article
- Identification of genes that promote or inhibit olfactory memory formation in Drosophila.Genetics · 2015Article
- Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.Molecular brain · 2015Article
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Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutant mice have been used successfully as a tool for investigating the mechanisms of memory at multiple levels, from genes to behavior. In most cases, manipulating a gene expressed in the brain impairs cognitive functions such as memory and their underlying cellular mechanisms, including synaptic plasticity. However, a remarkable number of mutations have been shown to enhance memory in mice. Understanding how to improve a system provides valuable insights into how the system works under normal conditions, because this involves understanding what the crucial components are. Therefore, more can be learned about the basic mechanisms of memory by studying mutant mice with enhanced memory. This review will summarize the genes and signaling pathways that are altered in the mutants with enhanced memory, as well as their roles in synaptic plasticity. Finally, I will discuss how knowledge of memory-enhancing mechanisms could be used to develop treatments for cognitive disorders associated with impaired plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.