Evidence map›Paper›PMID 24894131›Full record

ArticleVeterinary microbiology2014

Experimental infection of Rhipicephalus sanguineus with Ehrlichia chaffeensis.

Ryan T Stoffel, Jennifer C McClure, Marion M Butcher, Gayle C Johnson, Will Roland, Chuanmin Cheng, Kamesh R Sirigireddy, Roman Ganta, Kirstin Boughan, S A Ewing and 1 more

Open access · greenAbstract read
In one paragraph

Article in Veterinary microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Serological Evidence Supporting the Occurrence ofPathogens (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Article
  5. Co-Feeding Transmission of the Ehrlichia muris-Like Agent to Mice (Mus musculus).Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Ryan T StoffelDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.
Jennifer C McClureDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.
Marion M ButcherDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.
Gayle C JohnsonDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.
Will RolandDepartment of Internal Medicine Infectious Disease Division, University of Missouri, Columbia, MO 65211, USA.
Chuanmin ChengDepartment of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, USA.
Kamesh R SirigireddyDepartment of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, USA.
Roman GantaDepartment of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, USA.
Kirstin BoughanDepartment of Veterinary Preventive Medicine, The Ohio State University, Columbus, OH 43210, USA.
S A EwingDepartment of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK 74078, USA.
Roger W StichDepartment of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA. Electronic address: stichrw@missouri.edu.
University of Missouri · USKansas State University · USMissouri College · USOklahoma State University · USThe Ohio State University · US

Funding

Vector and Host Contributions to the Regulation of E. Chaffeensis Gene ExpressionR01AI070908 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI ROMAN R. GANTA · 2008 to 2026
$6.9M
Postdoctoral Training in Comparative MedicineT32OD011126 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Elizabeth C Bryda, Aaron Ericsson · 2012 to 2026
$3.4M
POSTDOCTORAL TRAINING IN LABORATORY ANIMAL MEDICINET32RR007004 · NCRR · UNIVERSITY OF MISSOURI-COLUMBIA · PI BRYDA, ELIZABETH C, FRANKLIN, CRAIG L · 1985 to 2011
$3.3M
Transmission of Ehrlichia chaffeensis by Adult TicksR01AI047932 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI STICH, ROGER WILLIAM · 2002 to 2006
$1.4M
NCRR NIH HHS T32 RR007004NIAID NIH HHS R01 AI047932NIAID NIH HHS R01 AI070908NIAID NIH HHS R01 AI47932NIH HHS T32 OD011126
6 · The paper itself

Abstract

Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis, is a tick-borne rickettsial pathogen that is infective to a wide range of mammals, including dogs and people. Amblyomma americanum, the lone star tick, is considered the primary vector of E. chaffeensis, but this pathogen has been detected in other tick species, including the brown dog tick, Rhipicephalus sanguineus. We hypothesized that the Arkansas strain of E. chaffeensis is infective to R. sanguineus, and used a novel PCR assay to test for acquisition of this pathogen by R. sanguineus and A. americanum ticks that were simultaneously fed on experimentally infected dogs. Although E. chaffeensis was not frequently detected in peripheral blood of these dogs, the pathogen was detected in both tick species and in canine lung, kidney, lymph node, bone marrow and frontal lobe samples. One dog (AFL) was maintained for several years, and ticks again acquired E. chaffeensis from this dog 566 days after intradermal inoculation with E. chaffeensis, but the pathogen was not detected in ticks fed on the same dog at 764 or 1086 days after the intradermal inoculation.

Indexed as

AnimalsDisease VectorsDNA, BacterialDog DiseasesDogsEhrlichia chaffeensisEhrlichiosisIxodidaeMalePolymerase Chain ReactionRhipicephalus sanguineusTime FactorsDNA, BacterialDogsEhrlichia chaffeensisRhipicephalus sanguineus

Identifiers

PMID24894131
PMCPMC4098862
OpenAlexW2074757931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.