ReviewParasitology research2014
Present-day anthelmintics and perspectives on future new targets.
Review in Parasitology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Unveiling Drimenol: A Phytochemical with Multifaceted Bioactivities.Plants (Basel, Switzerland) · 2024Review
- Antiparasitic activity of the steroid-rich extract ofVeterinary world · 2024Article
- Using newly optimized genetic tools to probe Strongyloides sensory behaviors.Molecular and biochemical parasitology · 2022Review
- The Current Directions of Searching for Antiparasitic Drugs.Molecules (Basel, Switzerland) · 2022Review
- Preliminary Phytochemical Composition andEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation.Veterinary research · 2021Article
- Inhibition of miR-99a-5p prevents allergen-driven airway exacerbations without compromising type-2 memory responses in the intestine following helminth infection.Mucosal immunology · 2021Article
- Sertaconazole induced toxicity in HeLa cells through mitotic arrest and inhibition of microtubule assembly.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- In vitro effects of tropisetron and granisetron against Echinococcus granulosus (s.s.) protoscoleces by involvement of calcineurin and calmodulin.Parasites & vectors · 2021Article
- Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria.Microorganisms · 2020Review
- Chemical composition and broad-spectrum anthelmintic activity of a cultivar of toothache plant,Pharmaceutical biology · 2020Article
- Phytochemical analysis and in vitro anthelmintic activity of Imperata cylindrica underground parts.BMC complementary medicine and therapies · 2020Article
- Natural Compounds from the Marine Brown AlgaPathogens (Basel, Switzerland) · 2020Article
- Intestinal cestodes of chicken are effectively killed by quinoline-rich extract ofVeterinary world · 2019Article
- Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors.International journal for parasitology. Drugs and drug resistance · 2019Article
- Probiotics and yogurt modulate oxidative stress and fibrosis in livers of Schistosoma mansoni-infected mice.BMC complementary and alternative medicine · 2019Article
- Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites.International journal for parasitology. Drugs and drug resistance · 2018Article
- Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research.International journal for parasitology. Drugs and drug resistance · 2016Article
- Pharmacological profile of Ascaris suum ACR-16, a new homomeric nicotinic acetylcholine receptor widely distributed in Ascaris tissues.British journal of pharmacology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In absence of vaccines for the majority of helminths, chemotherapy is still the mainstay for controlling human helminthiases. However, a limited number of drugs are available in the market to combat parasitic helminths in human. Besides, the development and spread of drug resistance have declined the use of most currently available anthelmintics. Clearly, availability of new anthelmintic agents will be essential in the next few years. More research into the mechanisms of drug actions and their targets are eminent for the discovery and development of novel anthelmintic agents. Recent drug discovery techniques mostly rely on mechanism-based screening of compounds on heterologously expressed targets in bacterial, mammalian or yeast cells. Although this is usually a successful approach, it is money- and time-consuming; meanwhile, pharmaceutical companies prefer the tested target that is chosen based on basic research. The nervous system is the site of action of several chemotherapeutics including pesticides and antinematode drugs; accordingly, the nervous system continues to be a promising target. Recent advances in exploring helminths' nervous system, neurotransmitters and receptors have paved the way for the development of potential agents targeting the nervous system and its components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.