Observational studyBMC cardiovascular disorders2014
Do gender differences in primary PCI mortality represent a different adherence to guideline recommended therapy? a multicenter observation.
Observational study in BMC cardiovascular disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Gender Differences in Treatment Delays, Management and Mortality among Patients with Acute Coronary Syndrome: A Systematic Review and Meta-analysis.Current cardiology reviews · 2023Pooled it
- Pooled it
- Sex differences in cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention.Journal of thoracic disease · 2025Article
- Sex Differences in Clinical Features and Outcomes in Patients with Acute Coronary Syndrome Treated with Bifurcation Stenting Using the Double-Kissing Culotte and Culotte Technique - 1-year Follow-up.Vascular health and risk management · 2025Article
- A Systematic Review of risk factors for major adverse cardiovascular events in patients with coronary heart disease who underwent percutaneous coronary intervention.Frontiers in physiology · 2025Article
- The procedural success of primary angioplasty in a tertiary care center in Pakistan.Pakistan journal of medical sciences · 2024Article
- Article
- Comparison between Invasive Intervention and Conservative Treatment in Patients with In-Hospital Myocardial Infarctions: Results from the Regional Myocardial Infarction Registry of Saxony-Anhalt (RHESA) Study.Journal of clinical medicine · 2024Article
- The Gender Spectrum of In-hospital Survival Post Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction: Exploring Age-driven Trends.Journal of the Saudi Heart Association · 2024Article
- Safety profile of bivalirudin in Chinese female patients undergoing percutaneous coronary intervention: a multi-center study.BMC cardiovascular disorders · 2022Article
- Gender Difference in Pain Management Among Adult Cancer Patients in Saudi Arabia: A Cross-Sectional Assessment.Frontiers in psychology · 2021Article
- Gender-based difference in early mortality among patients with ST-segment elevation myocardial infarction: insights from Kermanshah STEMI Registry.Journal of cardiovascular and thoracic research · 2020Article
- Behavioral Influence of Known Prognostic Markers on the Cardiologist's Decision following Acute Coronary Syndrome: the GRACE Score Paradox.Arquivos brasileiros de cardiologia · 2019Article
- Article
- Gender Disparities in Presentation, Management, and Outcomes of Acute Myocardial Infarction.Current cardiology reports · 2018Review
- Is female gender associated with worse outcome after ST elevation myocardial infarction?Indian heart journal · 2017Observational
- Sex differences in long-term mortality among acute myocardial infarction patients: Results from the ISAR-RISK and ART studies.PloS one · 2017Article
- Predictors of non-invasive therapy and 28-day-case fatality in elderly compared to younger patients with acute myocardial infarction: an observational study from the MONICA/KORA Myocardial Infarction Registry.BMC cardiovascular disorders · 2016Observational
- Population-level differences in revascularization treatment and outcomes among various United States subpopulations.World journal of cardiology · 2016Review
- Acute Coronary Syndromes in Women: Recent Treatment Trends and Outcomes.Clinical Medicine Insights. Cardiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is uncertain whether gender differences in outcome after primary percutaneous coronary intervention (PCI) are only attributable to different baseline characteristics or additional factors.
methodsDatabases of two German myocardial infarction network registries were combined with a total of 1104 consecutive patients admitted with acute ST-elevation myocardial infarction (STEMI) and treated according to standardized protocols.
resultsApproximately 25% of patients were females. Mean age (69 vs 61 years), incidence of diabetes (28% vs 20%), hypertension (68 vs 58%) and renal insufficiency (26% vs 19%) was significantly higher compared to males. Mean prehospital delay was numerically longer in females (227 vs 209 min) as was in hospital delay (35 vs 30 min). PCI was finally performed in 92% of females and 95% of males with comparable procedural success (95% vs 97%). Use of drug eluting stents (55% vs 68%) and application of GP 2b 3a blockers (75% vs 89%) was significantly less frequent in women. At discharge, prescription of beta blockers and lipid lowering drugs was also significantly lower in females (84% vs 90% and 71% vs 84%). Unadjusted in-hospital mortality was significantly higher in females (10% vs 5%) without attenuation after 12 months. Adjusted mortality however did not differ significantly between genders.
conclusionHigher unadjusted mortality in females after primary PCI was accompanied by significant differences in baseline characteristics, interventional approach and secondary prophylaxis in spite of the same standard of care. Lower guideline adherence seems to be less gender specific but rather a manifestation of the risk-treatment paradox.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.