ArticleInternational braz j urol : official journal of the Brazilian Society of Urology
Prognostic features for quality of life after radical cystectomy and orthotopic neobladder.
Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Pooled it
- Comparison of health-related quality of life (HRQoL) between ileal conduit diversion and orthotopic neobladder based on validated questionnaires: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Pooled it
- Female Sexual Function After Radical Treatment for MIBC: A Systematic Review.Journal of personalized medicine · 2025Review
- Radical Cystectomy with Ileal Orthotopic Neobladder after 70 Years Leads to Worse Health-Related Quality of Life.Journal of clinical medicine · 2024Article
- Role performance and factors affecting quality of life in bladder cancer survivors with ileal orthotopic neobladder.Asia-Pacific journal of oncology nursing · 2024Article
- Improvements in urinary symptoms, health-related quality of life, and psychosocial distress in the early recovery period after radical cystectomy and urinary diversion in 842 German bladder cancer patients: data from uro-oncological rehabilitation.World journal of urology · 2024Article
- Prospective evaluation of functional outcomes in 395 patients with an ileal neobladder 1 year after radical cystectomy.World journal of urology · 2023Article
- Health-related quality of life after curative treatment for muscle-invasive bladder cancer.Nature reviews. Urology · 2023Review
- Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development.Frontiers in oncology · 2023Article
- Neobladder "Function": Tips and Tricks for Surgery and Postoperative Management.Life (Basel, Switzerland) · 2022Review
- Current Management and Treatment of Extramammary Paget's Disease.Current treatment options in oncology · 2022Review
- Early continence after ileal neobladder: objective data from inpatient rehabilitation.World journal of urology · 2021Article
- Quality of life and functional outcomes after radical cystectomy with ileal orthotopic neobladder replacement for bladder cancer: a multicentre observational study.World journal of urology · 2021Observational
- Mucosal Invasion, but Not Incomplete Excision, Has Negative Impact on Long-Term Survival in Patients With Extramammary Paget's Disease.Frontiers in oncology · 2021Article
- Impact of Enhanced Recovery After Surgery on Long-Term Outcomes and Postoperative Recovery in Patients Undergoing Hepatectomy: A Retrospective Cohort Study.Cancer management and research · 2021Article
- Health-related quality of life after radical cystectomy and ileal orthotopic neobladder: effect of detailed continence outcomes.World journal of urology · 2019Article
- Orthotopic Neobladder Reconstruction: Patient Selection And Perspectives.Research and reports in urology · 2019Review
- Is robot-assisted surgery noninferior or real progress?Nature reviews. Urology · 2018Article
- Prospective evaluation of health-related quality of life after radical cystectomy: focus on peri- and postoperative complications.World journal of urology · 2017Article
- Functional results of hautmann neobladder with chimney modification and wallace ureteroileal anastomosis: initial experience with 22 patients.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyse prognostic features on quality of life (QoL) following radical cystectomy and urinary diversion via orthotopic neobladder in a single-centre patient cohort. MATERIALS AND
methodsPostoperative QoL of 152 patients was assessed retrospectively using the validated QLQ-C30 questionnaire. Potential associations of patient's quality of life including pre-and intraoperative characteristics, surgeon experience, postoperative time course, adjuvant therapies, and functional outcome were defined a priori and evaluated. Mann-Whitney-U-, Kruskal-Wallis-, Spearman correlation and post hoctesting were used. A multivariate analysis using a multiple logistic regression model was performed. A p value <0.05 was considered to be statistically significant.
resultsMedian follow-up was 48 months. Univariate analysis of prognostic features for health-related QoL revealed a significant impact of gender (p=0.019), performance status (p<0.001), experience of surgeon (>100 previous cystectomies, p=0.007), and nerve-sparing surgery (p=0.001). Patients who underwent secondary chemotherapy or radiotherapy had significant lower QLQ-C30 scores (p=0.04, p=0.02 respectively). Patients who were asymptomatic had a significantly higher quality of life (p<0.001). A significant impact of severity of incontinence based on ICIQ-SF score (p<0.001) and daily pad usage (p<0.001), existence of daytime incontinence (p<0.001), existence of urgency symptoms (p=0.007), and IIEF-5 score (p<0.001) could be observed. In multivariate analysis, independent prognostic relevance could be confirmed for preoperative ECOG performance status of 0 (p=0.020 vs. ECOG 1, p=0.047 vs. ECOG 2), experience of the respective surgeon (≥100 vs. <100 previous cystectomies, p=0.021), and daytime continence (p=0.032).
conclusionIn the present study, we report health-related QoL outcomes in a contemporary patient cohort and confirm preoperative ECOG status, surgeon experience and daytime incontinence as independent prognostic features for a good postoperative QoL.
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