ArticlePflugers Archiv : European journal of physiology2015
A role for transcription factor glial cell missing 2 in Ca2+ homeostasis in zebrafish, Danio rerio.
Article in Pflugers Archiv : European journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Acidification, warming and cadmium exposure disrupt zebrafish calcium metabolism, bone formation and swimming activity.The Journal of experimental biology · 2026Article
- GCM2 Silencing in Parathyroid Adenoma Is Associated With Promoter Hypermethylation and Gain of Methylation on Histone 3.The Journal of clinical endocrinology and metabolism · 2021Article
- Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes.Developmental cell · 2021Article
- The influence of environmental calcium on the branchial morphology in a catadromous fish.Environmental science and pollution research international · 2021Article
- Early-life stress influences ion balance in developing zebrafish (Danio rerio).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and HInternational journal of molecular sciences · 2020Article
- Zebrafish otolith biomineralization requires polyketide synthase.Mechanisms of development · 2019Article
- Zebrafish as a Model System for Investigating the Compensatory Regulation of Ionic Balance during Metabolic Acidosis.International journal of molecular sciences · 2018Review
- The Control of Calcium Metabolism in Zebrafish (Danio rerio).International journal of molecular sciences · 2016Review
- Osmoregulation in zebrafish: ion transport mechanisms and functional regulation.EXCLI journal · 2015Review
- Cortisol Regulates Acid Secretion of H(+)-ATPase-rich Ionocytes in Zebrafish (Danio rerio) Embryos.Frontiers in physiology · 2015Article
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Authors and funding
3 authors.
Funding
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Abstract
The present study investigated the role of the transcription factor, glial cell missing 2 (gcm2), in Ca(2+) regulation in zebrafish larvae. Translational gene knockdown of gcm2 decreased Ca(2+) uptake and the density of ionocytes expressing the epithelial Ca(2+) channel (ecac), and disrupted the overall Ca(2+) balance. Ca(2+) uptake and the expression of gcm2 messenger RNA (mRNA) were significantly elevated in larvae acclimated to low Ca(2+) water (25 μM); the stimulation of Ca(2+) uptake was not observed in fish experiencing gcm2 knockdown. Acclimation to acidic water (pH 4) significantly reduced whole-body Ca(2+) content owing to reduced Ca(2+) uptake and increased Ca(2+) efflux. However, ecac mRNA levels and the density of ecac-expressing ionocytes were increased in fish acclimated to acidic water, and maximal Ca(2+) uptake capacity (J MAX) was significantly increased when measured in control water (pH ~7.4). Acclimation of larvae to acidic water significantly increased gcm2 mRNA expression, and in gcm2 morphants, no such stimulation in Ca(2+) uptake was observed after their return to control water. Overexpression of gcm2 mRNA resulted in a significant increase in the numbers of ecac-expressing ionocytes and Ca(2+) uptake. These observations reveal a critical role for gcm2 in Ca(2+) homeostasis in zebrafish larvae.
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