ArticleBMC plant biology2014
SUMO E3 ligase AtMMS21 is required for normal meiosis and gametophyte development in Arabidopsis.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- SUMOylation: an emerging field of protein modification in horticultural plants.Horticulture research · 2026Review
- Newly unveiled meiosis elucidates the unreduced gamete frequency and its impact on the evolution of the Lemna minor complex.Journal of experimental botany · 2026Article
- Generation of viable hypomorphic and null mutant plants via CRISPR-Cas9 targeting mRNA splicing sites.Journal of plant research · 2025Article
- Cytological and transcriptomic analyses provide insights into the pollen fertility of synthetic allodiploid Brassica juncea hybrids.Plant cell reports · 2023Article
- The SMC5/6 complex subunit MMS21 regulates stem cell proliferation in rice.Plant cell reports · 2023Article
- The meiotic topoisomerase VI B subunit (MTOPVIB) is essential for meiotic DNA double-strand break formation in barley (Hordeum vulgare L.).Plant reproduction · 2023Article
- Cytosolic phosphoglucose isomerase is essential for microsporogenesis and embryogenesis in Arabidopsis.Plant physiology · 2023Article
- Crossover interference mechanism: New lessons from plants.Frontiers in cell and developmental biology · 2023Review
- Multiple Roles of SMC5/6 Complex during Plant Sexual Reproduction.International journal of molecular sciences · 2022Review
- Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies.Frontiers in endocrinology · 2022Review
- The SUMO ligase MMS21 profoundly influences maize development through its impact on genome activity and stability.PLoS genetics · 2021Article
- Defects in meiotic chromosome segregation lead to unreduced male gametes in Arabidopsis SMC5/6 complex mutants.The Plant cell · 2021Article
- Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants.Cellular and molecular life sciences : CMLS · 2021Review
- Structural Maintenance of Chromosomes 5/6 Complex Is Necessary for Tetraploid Genome Stability inFrontiers in plant science · 2021Article
- Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA.Frontiers in plant science · 2021Review
- Ubiquitination in Plant Meiosis: Recent Advances and High Throughput Methods.Frontiers in plant science · 2021Review
- Proteomic Analysis of Generative and Vegetative Nuclei Reveals Molecular Characteristics of Pollen Cell Differentiation inFrontiers in plant science · 2021Article
- Genetic and signalling pathways of dry fruit size: targets for genome editing-based crop improvement.Plant biotechnology journal · 2020Review
- The SMC5/6 Complex Subunit NSE4A Is Involved in DNA Damage Repair and Seed Development.The Plant cell · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMMS21 is a SUMO E3 ligase that is conserved in eukaryotes, and has previously been shown to be required for DNA repair and maintenance of chromosome integrity. Loss of the Arabidopsis MMS21 causes defective meristems and dwarf phenotypes.
resultsHere, we show a role for AtMMS21 during gametophyte development. AtMMS21 deficient plants are semisterile with shorter mature siliques and abortive seeds. The mms21-1 mutant shows reduced pollen number, and viability, and germination and abnormal pollen tube growth. Embryo sac development is also compromised in the mutant. During meiosis, chromosome mis-segregation and fragmentation is observed, and the products of meiosis are frequently dyads or irregular tetrads. Several transcripts for meiotic genes related to chromosome maintenance and behavior are altered. Moreover, accumulation of SUMO-protein conjugates in the mms21-1 pollen grains is distinct from that in wild-type.
conclusionsThus, these results suggest that AtMMS21 mediated SUMOylation may stabilize the expression and accumulation of meiotic proteins and affect gametophyte development.
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