ArticleJournal of assisted reproduction and genetics2014
The importance of the cleavage stage morphology evaluation for blastocyst transfer in patients with good prognosis.
Article in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Smooth endoplasmic reticulum aggregates in oocytes: a comparison of progestin-primed and GnRH antagonist IVF protocols.Journal of ovarian research · 2025Article
- Comparison of pregnancy outcomes between 4th day morula and 5th day blastocyst after embryo transfer: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- To Assess or Not to Assess: Reconsidering Day 3 Embryo Quality in Planned Freeze-All Blastocyst Cycles.Journal of personalized medicine · 2024Article
- Does cleavage stage morphology increase the discriminatory power of prediction in blastocyst transfer outcome?Journal of assisted reproduction and genetics · 2024Article
- Diminished ovarian reserve may not be associated with a poorer fresh cycle outcome in women < 38 years.Journal of ovarian research · 2023Article
- Does smooth endoplasmic reticulum aggregation in oocytes impact the chromosome aneuploidy of the subsequent embryos? A propensity score matching study.Journal of ovarian research · 2023Article
- The pregnancy outcomes of day-5 poor-quality and day-6 high-quality blastocysts in single blastocyst transfer cycles.Clinical and experimental reproductive medicine · 2023Article
- Impact of COVID-19 convalescence on pregnancy outcomes in patients undergoing IVF/ICSI during fresh ART cycles: a retrospective cohort study.Frontiers in endocrinology · 2023Article
- Investigating Impacts of CoronaVac Vaccination in Males onThe world journal of men's health · 2022Article
- Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study.Journal of clinical medicine · 2022Article
- Investigating the impact of SARS-CoV-2 infection on basic semen parameters and in vitro fertilization/intracytoplasmic sperm injection outcomes: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2022Article
- Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility andEClinicalMedicine · 2021Article
- Is the presence of an uncleaved embryo on day 3 a useful predictor of outcomes following day 5 transfer?Journal of assisted reproduction and genetics · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate: (i) the influence of morphology at cleavage stage on blastocyst formation and implantation, and (ii) whether the transfer of low-quality embryos on day-three would be a better approach than the transfer at blastocyst stage.
methodsThis study included 8,444 embryos obtained from 1,125 patients undergoing ICSI cycles between January/2011 and September/2013. The influence of the quality of the embryo on days-two and -three on blastocyst formation and implantation success was evaluated. Moreover, the implantation potential of low-quality embryos, at cleavage stage, transferred on day-three was compared with the implantation potential of low-quality embryos, at cleavage stage, transferred on day-five.
resultsLow-quality embryos on day-two had an approximate 20 % decreased chance of achieving the blastocyst stage, and blastocysts derived from low-quality embryos on day-two had a nearly 40 % decrease in the implantation chance. Low-quality embryos on day-three had a 30 % decreased chance of achieving the blastocyst stage, and blastocysts derived from low-quality embryos on day-three had an almost 40 % decreased implantation chance. The implantation rate didn't differ when low-quality embryos on the cleavage stage were transferred on day-three or left in culture and transferred on day-five.
conclusionsThe transfer of low-quality embryos on day-three is a better approach than transfer at the blastocyst stage. In addition, the embryo morphology evaluation at the cleavage stage is still needed for the selection of the embryo with the best implantation potential in extended embryo culture programmes.
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