ArticlePloS one2014
Carbon ion radiation inhibits glioma and endothelial cell migration induced by secreted VEGF.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Targeting stromal cells in tumor microenvironment as a novel treatment strategy for glioma.Cancer cell international · 2025Review
- Review of Recent Improvements in Carbon Ion Radiation Therapy in the Treatment of Glioblastoma.Advances in radiation oncology · 2024Review
- Basic and translational research on carbon-ion radiobiology.American journal of cancer research · 2023Review
- Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review.Frontiers in oncology · 2021Review
- Carbon Ion Irradiation Enhances the Anti-tumor Efficiency in Tongue Squamous Cell Carcinoma via Modulating the FAK Signaling.Frontiers in public health · 2021Article
- Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment.Photoacoustics · 2020Article
- Preliminary study on radiosensitivity to carbon ions in human breast cancer.Journal of radiation research · 2020Article
- Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance.Frontiers in oncology · 2020Review
- Bystander effects of ionizing radiation: conditioned media from X-ray irradiated MCF-7 cells increases the angiogenic ability of endothelial cells.Cell communication and signaling : CCS · 2019Article
- Carbon ion radiotherapy in the treatment of gliomas: a review.Journal of neuro-oncology · 2019Review
- Radiation-Induced Cardiovascular Disease: Mechanisms and Importance of Linear Energy Transfer.Frontiers in cardiovascular medicine · 2018Review
- Article
- Effects of Ion Irradiation on Seedlings Growth Monitored by Ultraweak Delayed Luminescence.PloS one · 2016Article
- Combining antiangiogenic therapy and radiation in nasopharyngeal carcinoma.Saudi medical journal · 2015Review
- Correlation between VEGFR2 rs2071559 polymorphism and glioma risk among Chinese population.International journal of clinical and experimental medicine · 2015Article
- Correction: Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF.PloS one · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the effects of carbon ion and X-ray radiation and the tumor microenvironment on the migration of glioma and endothelial cells, a key process in tumorigenesis and angiogenesis during cancer progression. C6 glioma and human microvascular endothelial cells were treated with conditioned medium from cultures of glioma cells irradiated at a range of doses and the migration of both cell types, tube formation by endothelial cells, as well as the expression and secretion of migration-related proteins were evaluated. Exposure to X-ray radiation-conditioned medium induced dose-dependent increases in cell migration and tube formation, which were accompanied by an upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-2 and -9 expression. However, glioma cells treated with conditioned medium of cells irradiated at a carbon ion dose of 4.0 Gy showed a marked decrease in migratory potential and VEGF secretion relative to non-irradiated cells. The application of recombinant VEGF165 stimulated migration in glioma and endothelial cells, which was associated with increased FAK phosphorylation at Tyr861, suggesting that the suppression of cell migration by carbon ion radiation could be via VEGF-activated FAK signaling. Taken together, these findings indicate that carbon ion may be superior to X-ray radiation for inhibiting tumorigenesis and angiogenesis through modulation of VEGF level in the glioma microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.