ArticleJournal of diabetes research2014
Gender differences in metabolic disorders and related diseases in Spontaneously Diabetic Torii-Lepr(fa) rats.
Article in Journal of diabetes research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- The impact of diabetes mellitus type 2 on the steroidogenesis of male Zucker Diabetic Fatty rats.Physiological research · 2022Article
- Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats.The Journal of veterinary medical science · 2022Article
- Ejaculatory dysfunction in men with diabetes mellitus.World journal of diabetes · 2021Review
- Potentiation of Acetylcholine-Induced Relaxation of Aorta in Male UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) Rats: Sex-Specific Responses.Frontiers in physiology · 2021Article
- Mesenteric arterial dysfunction in the UC Davis Type 2 Diabetes Mellitus rat model is dependent on pre-diabetic versus diabetic status and is sexually dimorphic.European journal of pharmacology · 2020Article
- Establishing equivalent diabetes in male and female Nos3-deficient mice results in a comparable onset of diabetic kidney injury.Physiological reports · 2019Article
- Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-LeprThe Journal of veterinary medical science · 2018Article
- Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats.Journal of toxicologic pathology · 2018Article
- Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Effect of paricalcitol on pancreatic oxidative stress, inflammatory markers, and glycemic status in diabetic rats.Irish journal of medical science · 2018Article
- Association of polymorphisms in LEPR with type 2 diabetes and related metabolic traits in a Chinese population.Lipids in health and disease · 2018Article
- Influence of Sex on Cognition and Peripheral Neurovascular Function in Diabetic Mice.Frontiers in neuroscience · 2018Article
- Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and Melatonin Secretion.International journal of endocrinology · 2018Article
- Changes in cardiac NaMolecular and cellular biochemistry · 2017Article
- Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.Scientific reports · 2017Article
- Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes.Journal of diabetes research · 2016Article
- Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions.World journal of gastroenterology · 2015Article
- Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin.Experimental animals · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Spontaneously Diabetic Torii Lepr(fa) (SDT fatty) rat is a novel type 2 diabetic model wherein both male and female rats develop glucose and lipid abnormalities from a young age. In this study, we investigated gender differences in abnormalities and related complications in SDT fatty rats. Food intake was higher in males compared to female rats; however, body weight was not different between genders. Progression of diabetes, including increases in blood glucose and declines in blood insulin, was observed earlier in male rats than in females, and diabetic grade was more critical in male rats. Blood lipids tended to increase in female rats. Gonadal dysfunction was observed in both male and female rats with aging. Microangiopathies, such as nephropathy, retinopathy, neuropathy, and osteoporosis, were seen in both genders, and pathological grade and progression were more significant in males. Qualitative and quantitative changes were observed for metabolic disease gender differences in SDT fatty rats. The SDT fatty rat is a useful model for researching gender differences in metabolic disorders and related diseases in diabetes with obesity.
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