ArticleGlobal advances in health and medicine2014
Frequency of abnormal fecal biomarkers in irritable bowel syndrome.
Article in Global advances in health and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations.United European gastroenterology journal · 2025Guideline
- Gut microbiota was modulated by moxibustion stimulation in rats with irritable bowel syndrome.Chinese medicine · 2018Article
- Faecal biomarker patterns in patients with symptoms of irritable bowel syndrome.Frontline gastroenterology · 2016Article
- Refractory Depression, Fatigue, Irritable Bowel Syndrome, and Chronic Pain: A Functional Medicine Case Report.The Permanente journal · 2016Article
- Food allergy in irritable bowel syndrome: The case of non-celiac wheat sensitivity.World journal of gastroenterology · 2015Review
- Validating biomarkers of treatable mechanisms in irritable bowel syndrome.Neurogastroenterology and motility · 2014Article
- Novel Testing Enhances Irritable Bowel Syndrome Medical Management: The IMMINENT Study.Global advances in health and medicine · 2014Article
- Current insights into the innate immune system dysfunction in irritable bowel syndrome.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PRIMARY STUDY
objectiveDetermine the frequency of abnormal fecal biomarker test results in patients with 13 irritable bowel syndrome (IBS)-related ICD-9 (International Statistical Classification of Diseases and Related Health Problems) codes. STUDY
designQuantitative review of de-identified records from patients in whom IBS was a possible diagnosis.
methodsRecords were selected for analysis if they included any of 13 IBS-related diagnostic codes and laboratory test results of fecal testing for all biomarkers of interest. Data collection was restricted to one 12-month period. Frequency distributions were calculated to identify rates of abnormal results for each biomarker within the total number of tests conducted in the eligible population.
resultsTwo thousand, two hundred fifty-six records were included in the study, of which 1867 (82.8%) included at least one abnormal value. Quantitative stool culture for beneficial bacteria (Lactobacillus and Bifidobacterium) indicated low growth suggestive of intestinal dysbiosis in 73.1% of records, followed by abnormally elevated eosinophil protein X (suggestive of food allergy) in 14.3%, elevated calprotectin (suggestive of inflammation) in 12.1%, detection of parasites in 7.5%, and low pancreatic elastase (suggestive of exocrine pancreatic insufficiency) in 7.1%.
conclusionsAbnormal fecal biomarkers are prevalent in patients with diagnoses suggestive of IBS. Abnormal fecal biomarker testing, if confirmed in additional independent clinical trials, could substantially reduce the economic costs associated with diagnosis and management of IBS.
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