Evidence map›Paper›PMID 24891949›Full record

ReviewPain research and treatment2014

Pathogenesis of painful diabetic neuropathy.

Amir Aslam, Jaipaul Singh, Satyan Rajbhandari

Open access · hybridAbstract readReview
In one paragraph

Review in Pain research and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 84 citations in OpenAlex.

  1. Trial
  2. Review
  3. Special Issue: "Molecular Diagnosis and Treatments of Diabetes Mellitus".International journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Beneficial effect ofHeliyon · 2024
    Article
  8. Article
  9. Physical Activity to Reduce Pain Scale in Diabetic Neuropathy Patients: A Scoping Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  10. Article
  11. Modulatory effects of photobiomodulation in the anterior cingulate cortex of diabetic rats.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Topical treatments for diabetic neuropathic pain.Experimental and therapeutic medicine · 2019
    Review
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amir AslamDepartment of Diabetes, Lancashire Teaching Hospital NHS Trust, Chorley and South Ribble District General Hospital, Preston Road, Chorley PR7 1PP, UK.ORCID 0000-0001-8924-6434
Jaipaul SinghSchool of Pharmacy and Biomedical Sciences and School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, Lancashire PR1 2HE, UK.ORCID 0000-0002-3200-3949
Satyan RajbhandariDepartment of Diabetes, Lancashire Teaching Hospital NHS Trust, Chorley and South Ribble District General Hospital, Preston Road, Chorley PR7 1PP, UK ; School of Pharmacy and Biomedical Sciences and School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, Lancashire PR1 2HE, UK.
University of Lancashire · GBChorley and South Ribble Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. It has a huge effect on a person's daily life, both physically and mentally. Despite huge advances in diabetes and neurology, the exact mechanism of pain causation in PDN is still not clear. The origin of pain could be in the peripheral nerves of the central nervous system. In this review, we discuss various possible mechanisms of the pathogenesis of pain in PDN. We discuss the role of hyperglycaemia in altering the physiology of peripheral nerves. We also describe central mechanisms of pain.

Identifiers

PMID24891949
PMCPMC4026988
OpenAlexW2064182983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.