ArticleThe Journal of biological chemistry2014
Nitrosothiol formation and protection against Fenton chemistry by nitric oxide-induced dinitrosyliron complex formation from anoxia-initiated cellular chelatable iron increase.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Antioxidant Action of Dinitrosyl Iron Complexes in Model Systems Containing CytochromeMolecules (Basel, Switzerland) · 2025Article
- Insights on the endogenous labile iron pool binding properties.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly.Biomolecules · 2024Article
- Effects of Nitrosyl Iron Complexes with Thiol, Phosphate, and Thiosulfate Ligands on Hemoglobin.International journal of molecular sciences · 2024Article
- Histidine-Bound Dinitrosyl Iron Complexes: Antioxidant and Antiradical Properties.International journal of molecular sciences · 2023Article
- Role of Nitric Oxide-Derived Metabolites in Reactions of Methylglyoxal with Lysine and Lysine-Rich Protein Leghemoglobin.International journal of molecular sciences · 2022Article
- Chronic High-Altitude Hypoxia Alters Iron and Nitric Oxide Homeostasis in Fetal and Maternal Sheep Blood and Aorta.Antioxidants (Basel, Switzerland) · 2022Article
- Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury.PloS one · 2022Article
- The Labile Iron Pool Reacts Rapidly and Catalytically with Peroxynitrite.Biomolecules · 2021Article
- Gaseous Nitric Oxide and Dinitrosyl Iron Complexes with Thiol-Containing Ligands as Potential Medicines that Can Relieve COVID-19.Biophysics · 2021Article
- The Peroxidatic Thiol of Peroxiredoxin 1 is Nitrosated by Nitrosoglutathione but Coordinates to the Dinitrosyl Iron Complex of Glutathione.Antioxidants (Basel, Switzerland) · 2020Article
- Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid.Oxidative medicine and cellular longevity · 2019Article
- Detection of dinitrosyl iron complexes by ozone-based chemiluminescence.Nitric oxide : biology and chemistry · 2018Article
- Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes.Nitric oxide : biology and chemistry · 2018Article
- The labile iron pool attenuates peroxynitrite-dependent damage and can no longer be considered solely a pro-oxidative cellular iron source.The Journal of biological chemistry · 2018Article
- Differential mitochondrial dinitrosyliron complex formation by nitrite and nitric oxide.Redox biology · 2018Article
- A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity.The Journal of biological chemistry · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
Dinitrosyliron complexes (DNIC) have been found in a variety of pathological settings associated with (•)NO. However, the iron source of cellular DNIC is unknown. Previous studies on this question using prolonged (•)NO exposure could be misleading due to the movement of intracellular iron among different sources. We here report that brief (•)NO exposure results in only barely detectable DNIC, but levels increase dramatically after 1-2 h of anoxia. This increase is similar quantitatively and temporally with increases in the chelatable iron, and brief (•)NO treatment prevents detection of this anoxia-induced increased chelatable iron by deferoxamine. DNIC formation is so rapid that it is limited by the availability of (•)NO and chelatable iron. We utilize this ability to selectively manipulate cellular chelatable iron levels and provide evidence for two cellular functions of endogenous DNIC formation, protection against anoxia-induced reactive oxygen chemistry from the Fenton reaction and formation by transnitrosation of protein nitrosothiols (RSNO). The levels of RSNO under these high chelatable iron levels are comparable with DNIC levels and suggest that under these conditions, both DNIC and RSNO are the most abundant cellular adducts of (•)NO.
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