Evidence map›Paper›PMID 24891465›Full record

ArticleThe American journal of tropical medicine and hygiene2014

Glucose-6-phosphate dehydrogenase deficiency A- variant in febrile patients in Haiti.

Tamar E Carter, Halley Maloy, Michael von Fricken, Yves St Victor, Jean R Romain, Bernard A Okech, Connie J Mulligan

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tamar E CarterGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti tamarec@ufl.edu.
Halley MaloyGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti.
Michael von FrickenGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti.
Yves St VictorGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti.
Jean R RomainGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti.
Bernard A OkechGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti.
Connie J MulliganGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haiti is one of two remaining malaria-endemic countries in the Caribbean. To decrease malaria transmission in Haiti, primaquine was recently added to the malaria treatment public health policy. One limitation of primaquine is that, at certain doses, primaquine can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd). In this study, we genotyped two mutations (A376G and G202A), which confer the most common G6PDd variant in West African populations, G6PDd A-. We estimated the frequency of G6PDd A- in a sample of febrile patients enrolled in an on-going malaria study who represent a potential target population for a primaquine mass drug administration. We found that 33 of 168 individuals carried the G6PDd A- allele (includes A- hemizygous males, A- homozygous or heterozygous females) and could experience toxicity if treated with primaquine. These data inform discussions on safe and effective primaquine dosing and future malaria elimination strategies for Haiti.

Indexed as

AllelesAdolescentAdultAgedAged, 80 and overAnemia, HemolyticAntimalarialsChildChild, PreschoolContraindicationsFemaleFeverGenotypeGlucosephosphate DehydrogenaseGlucosephosphate Dehydrogenase DeficiencyHaitiAntimalarialsGlucosephosphate DehydrogenasePrimaquine

Identifiers

PMID24891465
PMCPMC4125271
OpenAlexW1981549389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.