ArticleInfection and immunity2014
Colonization of cecum is important for development of persistent infection by Yersinia pseudotuberculosis.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- YmoA functions as a molecular stress sensor in Yersinia.Communications biology · 2025Article
- Role of the Yersinia pseudotuberculosis Virulence Plasmid in Pathogen-Phagocyte Interactions in Mesenteric Lymph Nodes.EcoSal Plus · 2021Review
- Spatiotemporal Variations in Growth Rate and Virulence Plasmid Copy Number duringInfection and immunity · 2021Article
- Autophagy and Intracellular Membrane Trafficking Subversion by PathogenicBiomolecules · 2020Review
- Genome-Scale Mapping Reveals Complex Regulatory Activities of RpoN in Yersinia pseudotuberculosis.mSystems · 2020Article
- Development of caecaloids to study host-pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum.International journal for parasitology · 2020Article
- Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation ofPathogens (Basel, Switzerland) · 2020Review
- Bread Feeding Is a Robust and More Physiological Enteropathogen Administration Method Compared to Oral Gavage.Infection and immunity · 2020Article
- One for All, but Not All for One: Social Behavior during Bacterial Diseases.Trends in microbiology · 2019Review
- Loss of CNFY toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency.PLoS pathogens · 2018Article
- An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using EnteropathogenicFrontiers in cellular and infection microbiology · 2018Article
- AllFrontiers in cellular and infection microbiology · 2018Review
- The Tat Substrate SufI Is Critical for the Ability of Yersinia pseudotuberculosis To Cause Systemic Infection.Infection and immunity · 2017Article
- Yersinia pseudotuberculosis Blocks Neutrophil Degranulation.Infection and immunity · 2016Article
- A Precise Temperature-Responsive Bistable Switch Controlling Yersinia Virulence.PLoS pathogens · 2016Article
- Article
- Transcriptomic profiling of Yersinia pseudotuberculosis reveals reprogramming of the Crp regulon by temperature and uncovers Crp as a master regulator of small RNAs.PLoS genetics · 2015Article
- Complete Protection against Pneumonic and Bubonic Plague after a Single Oral Vaccination.PLoS neglected tropical diseases · 2015Article
- Reprogramming of Yersinia from virulent to persistent mode revealed by complex in vivo RNA-seq analysis.PLoS pathogens · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yersiniosis is a human disease caused by the bacterium Yersinia pseudotuberculosis or Yersinia enterocolitica. The infection is usually resolved but can lead to postinfectious sequelae, including reactive arthritis and erythema nodosum. The commonly used Yersinia mouse infection model mimics acute infection in humans to some extent but leads to systemic infection and eventual death. Here, we analyzed sublethal infection doses of Y. pseudotuberculosis in mice in real time using bioluminescent imaging and found that infections using these lower doses result in extended periods of asymptomatic infections in a fraction of mice. In a search for the site for bacterial persistence, we found that the cecum was the primary colonization site and was the site where the organism resided during a 115-day infection period. Persistent infection was accompanied by sustained fecal shedding of cultivable bacteria. Cecal patches were identified as the primary site for cecal colonization during persistence. Y. pseudotuberculosis bacteria were present in inflammatory lesions, in localized foci, or as single cells and also in neutrophil exudates in the cecal lumen. The chronically colonized cecum may serve as a reservoir for dissemination of infection to extraintestinal sites, and a chronic inflammatory state may trigger the onset of postinfectious sequelae. This novel mouse model for bacterial persistence in cecum has potential as an investigative tool to unveil a deeper understanding of bacterial adaptation and host immune defense mechanisms during persistent infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.