ArticleObesity (Silver Spring, Md.)2014
Preliminary evidence of cognitive and brain abnormalities in uncomplicated adolescent obesity.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03461510 (Dysglycemia & Obesity), which is not on this map. Cited by 79 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dysglycemia & Obesity: Impact on the Brain in Adolescents With Type 2 Diabetes
Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Brain structural and functional changes in childhood and adolescent obesity: a systematic review of MRI studies.Frontiers in human neuroscience · 2026Pooled it
- The Executive Functions in Overweight and Obesity: A Systematic Review of Neuropsychological Cross-Sectional and Longitudinal Studies.Frontiers in psychology · 2019Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Brain and behavioral correlates of insulin resistance in youth with depression and obesity.Hormones and behavior · 2019Trial
- Impact of physical activity and exercise interventions on white matter integrity in overweight and obese populations: A systematic review and meta-analysis.Comprehensive psychoneuroendocrinology · 2026Review
- Association of Vitamin D and Weight Status With Neurodevelopmental Outcomes in a Large Pediatric Population: Cross-Sectional Study.JMIR public health and surveillance · 2026Article
- Review
- Executive Function Response to Moderate-to-High-Intensity Rope Skipping in Overweight Adolescents Aged 12-14: A Preliminary Study.Journal of functional morphology and kinesiology · 2025Article
- The association between small vessel disease and obstructive sleep apnea: a peak width of skeletonized mean diffusivity-based study.Sleep & breathing = Schlaf & Atmung · 2024Article
- GABA (gamma-aminobutyric acid) levels in dorsal anterior cingulate cortex are negatively associated with food motivation in a pediatric sample.Scientific reports · 2024Article
- Interplay between preclinical indices of obesity and neural signatures of fluid intelligence in youth.Communications biology · 2024Article
- Childhood obesity's effect on cognition and brain connectivity worsens with low family income.JCI insight · 2024Article
- The interconnection between obesity and executive function in adolescence: The role of the gut microbiome.Neuroscience and biobehavioral reviews · 2023Review
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Obesity is associated with decreased gray matter volume in children: a longitudinal study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective.Frontiers in neuroscience · 2023Review
- Endophenotypic correlates of cognitive function in reproductive-age individuals with polycystic ovary syndrome.F&S reports · 2022Article
- Altered brain activation in uncomplicated pediatric obesity: The second moment is more sensitive than the first.Brain and cognition · 2022Article
- Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia.BMC psychiatry · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo ascertain whether pediatric obesity without clinically significant insulin resistance (IR) impacts brain structure and function.
methodsThirty obese and 30 matched lean adolescents, all without clinically significant IR or a diagnosis of metabolic syndrome (MetS), received comprehensive endocrine, neuropsychological, and MRI evaluations.
resultsRelative to lean adolescents, obese non-IR adolescents had significantly lower academic achievement (i.e., arithmetic and spelling) and tended to score lower on working memory, attention, psychomotor efficiency, and mental flexibility. In line with our prior work on adolescent MetS, memory was unaffected in uncomplicated obesity. Reductions in the thickness of the orbitofrontal and anterior cingulate cortices as well as reductions of microstructural integrity in major white matter tracts without gross volume changes were also uncovered.
conclusionsIt was documented, for the first time, that adolescents with uncomplicated obesity already have subtle brain alterations and lower performance in selective cognitive domains. When interpreting these preliminary data in the context of our prior reports of similar, but more extensive brain findings in obese adolescents with MetS and T2DM, it was concluded that "uncomplicated" obesity may also result in subtle brain alterations, suggesting a possible dose effect with more severe metabolic dysregulation giving rise to greater abnormalities.
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Registered trials
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