ArticleAngewandte Chemie (International ed. in English)2014
Signal propagation in multi-layer DNAzyme cascades using structured chimeric substrates.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Programmable allosteric DNA regulations for molecular networks and nanomachines.Science advances · 2022Article
- Constructing DNA logic circuits based on the toehold preemption mechanism.RSC advances · 2021Article
- Allosteric DNAzyme-based DNA logic circuit: operations and dynamic analysis.Nucleic acids research · 2019Article
- Entropy-driven DNA logic circuits regulated by DNAzyme.Nucleic acids research · 2018Article
- Multiple advanced logic gates made of DNA-Ag nanocluster and the application for intelligent detection of pathogenic bacterial genes.Chemical science · 2018Article
- Article
- Enzyme-free amplified detection of circulating microRNA by making use of DNA circuits, a DNAzyme, and a catalytic hairpin assembly.Mikrochimica acta · 2017Article
- A Microsphere-Supported Lipid Bilayer Platform for DNA Reactions on a Fluid Surface.ACS applied materials & interfaces · 2017Article
- Continuous variables logicChemical science · 2017Article
- DNA Computing Systems Activated by Electrochemically-triggered DNA Release from a Polymer-brush-modified Electrode Array.Electroanalysis · 2017Article
- Bridging the Two Worlds: A Universal Interface between Enzymatic and DNA Computing Systems.Angewandte Chemie (International ed. in English) · 2015Article
- A unified sensor architecture for isothermal detection of double-stranded DNA, oligonucleotides, and small molecules.Chembiochem : a European journal of chemical biology · 2015Article
- Ternary DNA computing using 3 × 3 multiplication matrices.Chemical science · 2015Article
- Divide and control: split design of multi-input DNA logic gates.Chemical communications (Cambridge, England) · 2015Article
- Design of a biochemical circuit motif for learning linear functions.Journal of the Royal Society, Interface · 2014Article
- Biophysically inspired rational design of structured chimeric substrates for DNAzyme cascade engineering.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Signal propagation through enzyme cascades is a critical component of information processing in cellular systems. Although such systems have potential as biomolecular computing tools, rational design of synthetic protein networks remains infeasible. DNA strands with catalytic activity (DNAzymes) are an attractive alternative, enabling rational cascade design through predictable base-pair hybridization principles. Multi-layered DNAzyme signaling and logic cascades are now reported. Signaling between DNAzymes was achieved using a structured chimeric substrate (SCS) that releases a downstream activator after cleavage by an upstream DNAzyme. The SCS can be activated by various upstream DNAzymes, can be coupled to DNA strand-displacement devices, and is highly resistant to interference from background DNA. This work enables the rational design of synthetic DNAzyme regulatory networks, with potential applications in biomolecular computing, biodetection, and autonomous theranostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.