ArticleAnatomical record (Hoboken, N.J. : 2007)2014
The need for speed in rodent locomotion analyses.
Article in Anatomical record (Hoboken, N.J. : 2007), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
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- A perspective on the use of the CatWalk device to assess dynamic spasticity in rodent models.Frontiers in neuroscience · 2026Article
- Longitudinal Study and Characterization of Gait Impairment in a Mouse Model of SCA1.Cerebellum (London, England) · 2025Article
- Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer's disease.Scientific reports · 2025Article
- Spatiotemporal forelimb muscle activation during precise asymmetric stepping in rats.PloS one · 2025Article
- The relationship between changes in inflammation and locomotor function in sensory phenotypes of central neuropathic pain after spinal cord injury.Pain reports · 2024Article
- Sensory feedback and central neuronal interactions in mouse locomotion.Royal Society open science · 2024Article
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- Sensory Feedback and Central Neuronal Interactions in Mouse Locomotion.bioRxiv : the preprint server for biology · 2023Article
- 3D mouse pose from single-view video and a new dataset.Scientific reports · 2023Article
- Degeneration of muscle spindles in a murine model of Pompe disease.Scientific reports · 2023Article
- Neuroprotective and Immunomodulatory Effects of Probiotics in a Rat Model of Parkinson's Disease.Neurotoxicity research · 2023Article
- Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice.Journal of cachexia, sarcopenia and muscle · 2023Article
- A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models.Scientific reports · 2023Article
- Neurobehavioral deficits of mice expressing a low level of G127V mutant frataxin.Neurobiology of disease · 2023Article
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- Neurological scoring and gait kinematics to assess functional outcome in an ovine model of ischaemic stroke.Frontiers in neurology · 2023Article
- Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device - a narrative review.Frontiers in medicine · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Locomotion analysis is now widely used across many animal species to understand the motor defects in disease, functional recovery following neural injury, and the effectiveness of various treatments. More recently, rodent locomotion analysis has become an increasingly popular method in a diverse range of research. Speed is an inseparable aspect of locomotion that is still not fully understood, and its effects are often not properly incorporated while analyzing data. In this hybrid manuscript, we accomplish three things: (1) review the interaction between speed and locomotion variables in rodent studies, (2) comprehensively analyze the relationship between speed and 162 locomotion variables in a group of 16 wild-type mice using the CatWalk gait analysis system, and (3) develop and test a statistical method in which locomotion variables are analyzed and reported in the context of speed. Notable results include the following: (1) over 90% of variables, reported by CatWalk, were dependent on speed with an average R(2) value of 0.624, (2) most variables were related to speed in a nonlinear manner, (3) current methods of controlling for speed are insufficient, and (4) the linear mixed model is an appropriate and effective statistical method for locomotion analyses that is inclusive of speed-dependent relationships. Given the pervasive dependency of locomotion variables on speed, we maintain that valid conclusions from locomotion analyses cannot be made unless they are analyzed and reported within the context of speed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.