Evidence map›Paper›PMID 24890830›Full record

ReviewCold Spring Harbor perspectives in medicine2014

Diversification and specialization of touch receptors in skin.

David M Owens, Ellen A Lumpkin

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 98 citations in OpenAlex.

  1. Adhesive pyramidal thorn patches provide pain relief to athletes.The Kaohsiung journal of medical sciences · 2019
    Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Development and regeneration of Merkel cells.Current topics in developmental biology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. The human touch: A connected neuro-cellular skin-brain network.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Dorsolateral prefrontal cortex sensing analgesia.Biophysics and physicobiology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David M OwensDepartment of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032 Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032.
Ellen A LumpkinDepartment of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032 Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032.
Columbia University · US

Funding

Mechanisms of mechanosensory transduction in Merkel cellsR01AR051219 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LUMPKIN, ELLEN A · 2004 to 2020
$6.0M
Peripheral Mechanisms Governing Tactile Encoding During Normal Target RemodelingR01NS073119 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GERLING, GREGORY JOHN, LUMPKIN, ELLEN A · 2010 to 2016
$2.5M
Role of ultraviolet radiation in Merkel cell carcinogenesisR21ES020060 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWENS, DAVID M · 2011 to 2012
$443k
A cellular basis for age-related impaired tactile acuityR21AG044633 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWENS, DAVID M · 2014 to 2015
$434k
NIAMS NIH HHS R01 AR051219NIA NIH HHS R21 AG044633NIEHS NIH HHS R21 ES020060NINDS NIH HHS R01 NS073119
6 · The paper itself

Abstract

Our skin is the furthest outpost of the nervous system and a primary sensor for harmful and innocuous external stimuli. As a multifunctional sensory organ, the skin manifests a diverse and highly specialized array of mechanosensitive neurons with complex terminals, or end organs, which are able to discriminate different sensory stimuli and encode this information for appropriate central processing. Historically, the basis for this diversity of sensory specializations has been poorly understood. In addition, the relationship between cutaneous mechanosensory afferents and resident skin cells, including keratinocytes, Merkel cells, and Schwann cells, during the development and function of tactile receptors has been poorly defined. In this article, we will discuss conserved tactile end organs in the epidermis and hair follicles, with a focus on recent advances in our understanding that have emerged from studies of mouse hairy skin.

Indexed as

AnimalsEpidermal CellsEpidermisHair FollicleHumansMechanoreceptorsMerkel CellsMiceTouch

Identifiers

PMID24890830
PMCPMC4031957
OpenAlexW2123158722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.