ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
A novel clinically relevant segmentation method and corresponding maximal ischemia score to risk-stratify patients undergoing myocardial perfusion scintigraphy.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Update of the Brazilian Guideline on Nuclear Cardiology - 2020.Arquivos brasileiros de cardiologia · 2020Guideline
- Comparative analysis between myocardial perfusion reserve and maximal ischemia score at single photon emission computed tomography with new-generation cadmium-zinc-telluride cameras.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Observational
- Myocardial-coronary fusion imaging with positron emission tomography and computed tomography: Benchmarking and slingshotting.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Hybrid anatomo-functional imaging of coronary artery disease: Beneficial irrespective of its core components.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- What is this image? 2018: Image 1 result : The value of diastole perfusion.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Prognostic accuracy of myocardial perfusion imaging in octogenarians.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Bridging the Atlantic gap in clinical guidelines for non-ST-elevation acute coronary syndromes.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- ISCHEMIA, to revascularize or not to revascularize.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Impact of coronary revascularization vs medical therapy on ischemia among stable patients with or suspected coronary artery disease undergoing serial myocardial perfusion scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Prognostic impact of location and extent of vessel-related ischemia at myocardial perfusion scintigraphy in patients with or at risk for coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Review of cardiovascular imaging in The Journal of Nuclear Cardiology in 2014: Part 2 of 2: Myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Novel approaches to risk stratification with semi-quantitative scoring systems in nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMyocardial perfusion scintigraphy (MPS) represents a key prognostic tool, but its predictive yield is far from perfect. We developed a novel clinically relevant segmentation method and a corresponding maximal ischemia score (MIS) in order to risk-stratify patients undergoing MPS.
methodsPatients referred for MPS were identified, excluding those with evidence of myocardial necrosis or prior revascularization. A seven-region segmentation approach was adopted for left ventricular myocardium, with a corresponding MIS distinguishing five groups (no, minimal, mild, moderate, or severe ischemia). The association between MIS and clinical events was assessed at 1 year and at long-term follow-up.
resultsA total of 8,714 patients were included, with a clinical follow-up of 31 ± 20 months. Unadjusted analyses showed that subjects with a higher MIS were significantly different for several baseline and test data, being older, having lower ejection fraction, and achieving lower workloads (P < .05 for all). Adverse outcomes were also more frequent in patients with higher levels of ischemia, including cardiac death, myocardial infarction (MI), and their composites (P < .05 for all). Differences in adverse events remained significant even after extensive multivariable adjustment (hazard ratio for each MIS increment = 1.57 [1.29-1.90], P < .001 for cardiac death; 1.19 [1.04-1.36], P = .013 for MI; 1.23 [1.09-1.39], P = .001 for cardiac death/MI).
conclusionsOur novel segmentation method and corresponding MIS efficiently yield satisfactory prognostic information.
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