Evidence map›Paper›PMID 24890274›Full record

ReviewFertility and sterility2014

Why we should transfer frozen instead of fresh embryos: the translational rationale.

Rachel Weinerman, Monica Mainigi

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 66 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 5 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03954587 terminatednot on this mapstarted 2019, after this paper: background citation

What is the Optimal Cycle Regimen for Frozen- Thawed Embryo Transfer Cycles: Spontaneous Natural Cycles Versus Hormonal Replacement Treatment (HRT) Cycles

TypeobservationalSponsorART Fertility Clinics LLCRan2019 to 2020Enrolled4ConditionsInfertility, Female Infertility, Pregnancy Early
NCT04417569 completednot on this mapstarted 2021, after this paper: background citation

A Proof of Concept Study to Determine the Rise of Progesterone Levels After Human Chorionic Gonadotrophin (hCG) Trigger in Stimulated Cycles of IVF/ICSI

TypeobservationalSponsorART Fertility Clinics LLCRan2021 to 2021Enrolled10ConditionsInfertility, Infertility, Female, IVF, hCGArmshCG, Ultrasound, Blood test
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 5 syntheses or guidelines pooled it, 190 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rachel WeinermanDivision of Reproductive Endocrinology and Infertility, University of Pennsylvania, Philadelphia, Pennsylvania.
Monica MainigiDivision of Reproductive Endocrinology and Infertility, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: mainigim@uphs.upenn.edu.
University of Pennsylvania · US

Funding

REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
A National Training Program in Reproductive MedicineT32HD040135 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI COUTIFARIS, CHRISTOS · 2002 to 2016
$3.6M
NICHD NIH HHS K12 HD000849NICHD NIH HHS T32 HD040135
6 · The paper itself

Abstract

Epidemiologic studies have shown an increased rate of adverse perinatal outcomes, including small for gestational age (SGA) births, in fresh in vitro fertilization (IVF) cycles compared with frozen embryo transfer cycles. This increase is not seen in the donor oocyte population, suggesting that it is the peri-implantation environment created after superovulation that is responsible for these changes. During a fresh IVF cycle, multiple corpora lutea secrete high levels of hormones and other factors that can affect the endometrium and the implanting embryo. In this review, we discuss both animal and human data demonstrating that superovulation has significant effects on the endometrium and embryo. Additionally, potential mechanisms for the adverse effects of gonadotropin stimulation on implantation and placental development are proposed. We think that these data, along with the growing body of epidemiologic evidence, support the proposal that frozen embryo transfer should be considered preferentially, particularly in high responders, as a means to potentially decrease at least some of the adverse perinatal outcomes associated with IVF.

Indexed as

CryopreservationEmbryo, MammalianEmbryo TransferFertilization in VitroOvulation InductionTranslational Research, BiomedicalAnimalsEmbryo ImplantationEndometriumFemaleFertilityFertility Agents, FemaleHumansInfertilityPregnancyPregnancy RateFertility Agents, Femalefrozen embryo transferimplantationIn vitro fertilizationplacentationsuperovulation

Identifiers

PMID24890274
PMCPMC4435545
OpenAlexW1963607795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.