Evidence map›Paper›PMID 24890098›Full record

ArticleJournal of the International Society of Sports Nutrition2014

Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation.

Mahdi Garelnabi, Halleh Mahini, Thomas Wilson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Society of Sports Nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  5. Article
  6. Research progress of quercetin in cardiovascular disease.Frontiers in cardiovascular medicine · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mahdi GarelnabiDepartment of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, 3 Solomont Way, Suite 4 01854, Lowell, MA, USA.
Halleh MahiniDepartment of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, 3 Solomont Way, Suite 4 01854, Lowell, MA, USA.
Thomas WilsonDepartment of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, 3 Solomont Way, Suite 4 01854, Lowell, MA, USA.
University of Massachusetts Lowell · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesWe proposed that mice supplemented with quercetin, a class of flavonoids known to have antioxidant and anti-inflammatory properties, will have profound effects on the pathophysiology of atherosclerosis when combined with exercise. STUDY

designForty C57BL6 LDLr -/- mice were divided into four groups (n = 10): control untreated (NN); control group supplemented with 100 μg/day of quercetin (NQ); exercise group (EN); and exercise group supplemented with 100 μg/day of quercetin (EQ). All animals were fed atherogenic diet. The exercise groups were run on a treadmill for 30 minutes, 15 m/min for 5 days/week for 30 days. After 30 day animals were sacrificed and tissues were harvested. RESULTS AND

conclusionMice supplemented with quercetin during exercise sessions had 78% atherosclerotic plaque reduction compared to control mice and 40% less atherosclerotic plaque formation compared to control group supplemented with quercetin. The manifestation of the combination of quercetin supplementation with exercise was more evident in the pro-reverse cholesterol transport genes, indicating a plausible mechanism for their combined beneficial effect. The pathogenesis of atherosclerosis, the major cause of cardiovascular diseases (CVD), is multifactorial and therefore its treatment approaches and the ability to regress the plaque are complicated. Data from research on animal models and clinical studies have indicated that moderate daily exercise can alleviate the risk for the development of atherosclerotic plaques, while the same has not been true for the supplementation of antioxidants.

Indexed as

ExerciseFlavonoidsInflammationLipoproteinsQuercetin

Identifiers

PMID24890098
PMCPMC4041042
OpenAlexW2150869696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.