SynthesisBMJ supportive & palliative care2016
Controlled rehabilitative and supportive care intervention trials in patients with high-grade gliomas and their caregivers: a systematic review.
Synthesis in BMJ supportive & palliative care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- What are the experiences of supportive care in people affected by brain cancer and their informal caregivers: A qualitative systematic review.Journal of cancer survivorship : research and practice · 2024Pooled it
- Reforming support systems of newly diagnosed brain cancer patients: a systematic review.Journal of neuro-oncology · 2022Pooled it
- Rehabilitation therapy for patients with glioma: A PRISMA-compliant systematic review and meta-analysis.Medicine · 2020Pooled it
- Interventions to help support caregivers of people with a brain or spinal cord tumour.The Cochrane database of systematic reviews · 2019Pooled it
- Carer preparedness improved by providing a supportive educational intervention for carers of patients with high-grade glioma: RCT results.Journal of neuro-oncology · 2023Trial
- Online Couple-Based Meditation Intervention for Patients With Primary or Metastatic Brain Tumors and Their Partners: Results of a Pilot Randomized Controlled Trial.Journal of pain and symptom management · 2020Trial
- Cognitive rehabilitation for executive dysfunction in brain tumor patients: a pilot randomized controlled trial.Journal of neuro-oncology · 2019Trial
- Trial
- Trial
- Mental health and suicidality in glioblastoma patients in germany - a multicenter cross-sectional observational study protocol (SHINE-GLIO Study).Neurological research and practice · 2026Article
- Coping with primary brain tumors together: a scoping review of dyadic psychosocial interventions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- A Supportive Group Intervention for Caregivers to Patients Diagnosed With Glioblastoma: Protocol for the SUGRI Study.JMIR research protocols · 2026Article
- "It's a club nobody wanted to join, but we're there": Focus groups on end-of-life care experiences and long-term outcomes of bereaved neuro-oncology caregivers.Palliative care and social practice · 2026Article
- Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function.PM & R : the journal of injury, function, and rehabilitation · 2025Article
- Polyphenol-Based Nutritional Strategies Combined With Exercise for Brain Function and Glioma Control: Focus on Epigenetic Modifications, Cognitive Function, Learning and Memory Processes.Food science & nutrition · 2025Review
- Rehabilitation nursing for brain tumor patients: a scoping review.BMC medical education · 2025Article
- Physical activity and glioblastoma: a paradigm shift in neuro-oncology therapy.Frontiers in oncology · 2025Review
- Inequalities in access to neuro-oncology supportive care and rehabilitation: A survey of healthcare professionals' perspectives.Neuro-oncology practice · 2024Article
- Rehabilitation in People Living with Glioblastoma: A Narrative Review of the Literature.Cancers · 2024Review
- Low-frequency repetitive transcranial magnetic stimulation in patients with motor deficits after brain tumor resection: a randomized, double-blind, sham-controlled trial.Frontiers in oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients diagnosed with high-grade gliomas experience a varying and complex symptom burden, and face a high mortality rate. As a consequence, patients with high-grade gliomas and their caregivers have imminent and changing rehabilitative and supportive care needs.
objectivesTo give a detailed overview of non-pharmacological rehabilitative and supportive care interventions for patients with high-grade gliomas and/or their caregivers, and provide an appraisal of the methodological quality of these studies.
methodPubMed, Cumulative Index of Nursing and Allied Health Literature and Embase were searched for literature published from 1995 to May 2013. Data from eight studies were reviewed for substantive methods and results. Methodological quality was described and assessed using the scoring system for appraising mixed methods research and concomitantly appraising qualitative, quantitative and mixed methods primary studies in mixed study reviews.
resultsThe search yielded 914 unique publications, of which 9 were classified eligible for this review. There is preliminary evidence that cognitive group therapy improves memory skills in patients with high-grade gliomas, early physical training improves functional outcome and massage therapy reduces stress. Patients and caregivers found that telephone follow-up and a specialist nurse function was an effective and useful way to achieve information and support. Finally, psycho-education increased feelings of mastery among caregivers.
conclusionsAs evidence is beginning to emerge, there is a need for well-designed longitudinal and randomised controlled trials of non-pharmacological interventions in high-grade glioma patients and their caregivers in order to develop clinical guidelines for supportive and rehabilitative approaches in this unique population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.