Evidence map›Paper›PMID 24889770›Full record

ReviewNature reviews. Clinical oncology2014

Management of colorectal cancer presenting with synchronous liver metastases.

Ajith K Siriwardena, James M Mason, Saifee Mullamitha, Helen C Hancock, Santhalingam Jegatheeswaran

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Clinical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02456285 completednot on this mapstarted 2015, after this paper: background citation

Colorectal Cancer With Liver-limited Synchronous Metastases: an Inception Cohort Study of Standardised Care Pathways

TypeobservationalSponsorManchester University NHS Foundation TrustRan2015 to 2017Enrolled123ConditionsColorectal Neoplasms, Liver Neoplasms, Neoplasm MetastasisArmsPrimary/Bowel-first Surgery, Liver-first surgery, Synchronous resection surgery, No surgery
NCT05362825 unknown statusnot on this mapstarted 2022, after this paper: background citation

Surgery Outcome Treated by Neo-adjuvant Chemotherapy FOLFOXIRI Regimen in Colorectal Cancer With Liver-limited Synchronous Metastases

TypeobservationalSponsorCho Ray HospitalRan2022 to 2025Enrolled89ConditionsLiver Metastasis Colon Cancer, Synchronous NeoplasmArmsNeo-adjuvant Chemotherapy FOLFOXIRI Regimen, synchronous resection surgery
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 175 citations in OpenAlex.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ajith K SiriwardenaHepatobiliary Surgery Unit, Manchester Biomedical Research Centre and NIHR Greater Manchester Research Network, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
James M MasonDurham Clinical Trials Unit, School of Medicine, Pharmacy and Health, Wolfson Research Institute, Durham University Queen's Campus, University Boulevard, Stockton-on-Tees TS17 6BH, UK.
Saifee MullamithaDepartment of Medical Oncology, Christie Hospital, Wilmslow Road, Manchester M20 4BX, UK.
Helen C HancockDurham Clinical Trials Unit, School of Medicine, Pharmacy and Health, Wolfson Research Institute, Durham University Queen's Campus, University Boulevard, Stockton-on-Tees TS17 6BH, UK.
Santhalingam JegatheeswaranHepatobiliary Surgery Unit, Manchester Biomedical Research Centre and NIHR Greater Manchester Research Network, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
The Christie Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to a fifth of patients with colorectal cancer (CRC) present with synchronous hepatic metastases. In patients with CRC who present without intestinal obstruction or perforation and in whom comprehensive whole-body imaging confirms the absence of extrahepatic disease, evidence indicates a state of equipoise between several different management pathways, none of which has demonstrated superiority. Neoadjuvant systemic chemotherapy is advocated by current guidelines, but must be integrated with surgical management in order to remove the primary tumour and liver metastatic burden. Surgery for CRC with synchronous liver metastases can take a number of forms: the 'classic' approach, involving initial colorectal resection, interval chemotherapy and liver resection as the final step; simultaneous removal of the liver and bowel tumours with neoadjuvant or adjuvant chemotherapy; or a 'liver-first' approach (before or after systemic chemotherapy) with removal of the colorectal tumour as the final procedure. In patients with rectal primary tumours, the liver-first approach can potentially avoid rectal surgery in patients with a complete response to chemoradiotherapy. We overview the importance of precise nomenclature, the influence of clinical presentation on treatment options, and the need for accurate, up-to-date surgical terminology, staging tests and contemporary management options in CRC and synchronous hepatic metastatic disease, with an emphasis on multidisciplinary care.

Indexed as

Colorectal NeoplasmsHumansLiver NeoplasmsNeoplasm Staging

Identifiers

PMID24889770
OpenAlexW2077570188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.