ArticleAngewandte Chemie (International ed. in English)2014
Heterogeneous solution NMR signal amplification by reversible exchange.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 100 citations in OpenAlex.
- Single-chain fluorinated Ir-NHC catalysts for efficient SABRE pyruvate hyperpolarization with average residual iridium below 100 ppb.RSC advances · 2026Article
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- In vivo Metabolic Sensing of Hyperpolarized [1-Angewandte Chemie (International ed. in English) · 2024Article
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- LC-Photo-CIDNP hyperpolarization of biomolecules bearing a quasi-isolated spin pair: Magnetic-Field dependence via a rapid-shuttling device.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024Article
- Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-Journal of the American Chemical Society · 2024Article
- Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-Journal of magnetic resonance open · 2023Article
- Water-Compatible and Recyclable Heterogeneous SABRE Catalyst for NMR Signal Amplification.JACS Au · 2023Article
- Iron-CatalyzedJournal of the American Chemical Society · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-Metabolites · 2023Article
- RapidAnalytical chemistry · 2022Article
- Selective Isotope Labeling and LC-Photo-CIDNP Enable NMR Spectroscopy at Low-Nanomolar Concentration.Journal of the American Chemical Society · 2022Article
- Rapid SABRE Catalyst Scavenging Using Functionalized Silicas.Molecules (Basel, Switzerland) · 2022Article
- Rational ligand choice extends the SABRE substrate scope.Chemical communications (Cambridge, England) · 2020Article
- Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design.Nature communications · 2018Article
- Parahydrogen-Based Hyperpolarization for Biomedicine.Angewandte Chemie (International ed. in English) · 2018Review
- Facile Removal of Homogeneous SABRE Catalysts for Purifying Hyperpolarized Metronidazole, a Potential Hypoxia Sensor.The journal of physical chemistry. C, Nanomaterials and interfaces · 2018Article
- Toward Cleavable Metabolic/pH Sensing "Double Agents" Hyperpolarized by NMR Signal Amplification by Reversible Exchange.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Hyperpolarized NMR Spectroscopy: d-DNP, PHIP, and SABRE Techniques.Chemistry, an Asian journal · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A novel variant of an iridium-based organometallic catalyst was synthesized and used to enhance the NMR signals of pyridine in a heterogeneous phase by immobilization on polymer microbead solid supports. Upon administration of parahydrogen (pH2) gas to a methanol mixture containing the HET-SABRE catalyst particles and the pyridine, up to fivefold enhancements were observed in the (1)H NMR spectra after sample transfer to high field (9.4 T). Importantly, enhancements were not due to any residual catalyst molecules in solution, thus supporting the true heterogeneity of the SABRE process. Further significant improvements may be expected by systematic optimization of experimental parameters. Moreover, the heterogeneous catalyst is easy to separate and recycle, thus opening a door to future potential applications varying from spectroscopic studies of catalysis, to imaging metabolites in the body without concern of contamination from expensive and potentially toxic metal catalysts or accompanying organic molecules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.