ArticleAnnals of biomedical engineering2014
Rapid antimicrobial susceptibility testing with electrokinetics enhanced biosensors for diagnosis of acute bacterial infections.
Article in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Ultrafast Electrothermal Flow-Enhanced Magneto Biosensor for Highly Sensitive Protein Detection in Whole Blood.Angewandte Chemie (International ed. in English) · 2022Article
- Diagnosis of Bloodstream Infections: An Evolution of Technologies towards Accurate and Rapid Identification and Antibiotic Susceptibility Testing.Antibiotics (Basel, Switzerland) · 2022Review
- Rapid and real-time monitoring of bacterial growth against antibiotics in solid growth medium using a contactless planar microwave resonator sensor.Scientific reports · 2021Article
- Innovative optofluidics and microscopy-based rapid analysis of pathogens.Biomedical optics express · 2020Article
- Label-Free Electrochemical Microfluidic Chip for the Antimicrobial Susceptibility Testing.Antibiotics (Basel, Switzerland) · 2020Article
- Surfactant-enhanced DNA accessibility to nuclease accelerates phenotypic β-lactam antibiotic susceptibility testing of Neisseria gonorrhoeae.PLoS biology · 2020Article
- Modern Tools for Rapid Diagnostics of Antimicrobial Resistance.Frontiers in cellular and infection microbiology · 2020Review
- Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Current and Emerging Methods of Antibiotic Susceptibility Testing.Diagnostics (Basel, Switzerland) · 2019Review
- Antimicrobial Peptides: Powerful Biorecognition Elements to Detect Bacteria in Biosensing Technologies.Molecules (Basel, Switzerland) · 2018Review
- Molecular Biosensors for Electrochemical Detection of Infectious Pathogens in Liquid Biopsies: Current Trends and Challenges.Sensors (Basel, Switzerland) · 2017Review
- A Multiplex Electrochemical Biosensor for Bloodstream Infection Diagnosis.SLAS technology · 2017Article
- Long-range electrothermal fluid motion in microfluidic systems.International journal of heat and mass transfer · 2016Article
- Article
- A UAV-Mounted Whole Cell Biosensor System for Environmental Monitoring Applications.IEEE transactions on nanobioscience · 2015Article
- AC Electrokinetics of Physiological Fluids for Biomedical Applications.Journal of laboratory automation · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Rapid pathogen detection and antimicrobial susceptibility testing (AST) are required in diagnosis of acute bacterial infections to determine the appropriate antibiotic treatment. Molecular approaches for AST are often based on the detection of known antibiotic resistance genes. Phenotypic culture analysis requires several days from sample collection to result reporting. Toward rapid diagnosis of bacterial infection in non-traditional healthcare settings, we have developed a rapid AST approach that combines phenotypic culture of bacterial pathogens in physiological samples and electrochemical sensing of bacterial 16S rRNA. The assay determines the susceptibility of pathogens by detecting bacterial growth under various antibiotic conditions. AC electrokinetic fluid motion and Joule heating induced temperature elevation are optimized to enhance the sensor signal and minimize the matrix effect, which improve the overall sensitivity of the assay. The electrokinetics enhanced biosensor directly detects the bacterial pathogens in blood culture without prior purification. Rapid determination of the antibiotic resistance profile of Escherichia coli clinical isolates is demonstrated.
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Registered trials
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