ArticleProceedings of the National Academy of Sciences of the United States of America2014
Differential targeting of VDAC3 mRNA isoforms influences mitochondria morphology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- TheProceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Ribosome biogenesis in plants requires the nuclear envelope and mitochondria localized OPENER complex.Nature communications · 2025Article
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- mRNA Localization to the Endoplasmic Reticulum in Plant Endosperm Cells.International journal of molecular sciences · 2022Review
- FRIENDLY (FMT) is an RNA binding protein associated with cytosolic ribosomes at the mitochondrial surface.The Plant journal : for cell and molecular biology · 2022Article
- Challenges Facing CRISPR/Cas9-Based Genome Editing in Plants.Frontiers in plant science · 2022Review
- Mitochondrial ion channels in cardiac function.American journal of physiology. Cell physiology · 2021Review
- VDAC1 Negatively Regulates Floral Transition inInternational journal of molecular sciences · 2021Article
- Intracellular mRNA transport and localized translation.Nature reviews. Molecular cell biology · 2021Review
- FMT, a protein that affects mitochondrial distribution, interacts with translation-related proteins in Arabidopsis thaliana.Plant cell reports · 2021Article
- The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization.Frontiers in genetics · 2021Review
- Review
- The increasing diversity and complexity of the RNA-binding protein repertoire in plants.Proceedings. Biological sciences · 2020Article
- Article
- mRNA Localization in Plant Cells.Plant physiology · 2020Review
- UTR-Dependent Control of Gene Expression in Plants.Trends in plant science · 2018Review
- Efficient Detection of Long dsRNAFrontiers in plant science · 2018Article
- Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant.Nucleic acids research · 2016Article
- Calcium Flux across Plant Mitochondrial Membranes: Possible Molecular Players.Frontiers in plant science · 2016Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular targeting of mRNAs has recently emerged as a prevalent mechanism to control protein localization. For mitochondria, a cotranslational model of protein import is now proposed in parallel to the conventional posttranslational model, and mitochondrial targeting of mRNAs has been demonstrated in various organisms. Voltage-dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane and the major transport pathway for numerous metabolites. Four nucleus-encoded VDACs have been identified in Arabidopsis thaliana. Alternative cleavage and polyadenylation generate two VDAC3 mRNA isoforms differing by their 3' UTR. By using quantitative RT-PCR and in vivo mRNA visualization approaches, the two mRNA variants were shown differentially associated with mitochondria. The longest mRNA presents a 3' extension named alternative UTR (aUTR) that is necessary and sufficient to target VDAC3 mRNA to the mitochondrial surface. Moreover, aUTR is sufficient for the mitochondrial targeting of a reporter transcript, and can be used as a tool to target an unrelated mRNA to the mitochondrial surface. Finally, VDAC3-aUTR mRNA variant impacts mitochondria morphology and size, demonstrating the role of mRNA targeting in mitochondria biogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.