ArticleProceedings of the National Academy of Sciences of the United States of America2014
The Irish potato famine pathogen Phytophthora infestans originated in central Mexico rather than the Andes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unveiling the frontiers of potato disease research through bibliometric analysis.Frontiers in microbiology · 2024Pooled it
- High Genotypic Polymorphism and Extensive Gene Flow Drive the Population Dynamics of Potato Oomycete Pathogen,Journal of fungi (Basel, Switzerland) · 2026Article
- Taxonomy, biogeography and evolution of thirty-four taxa inStudies in mycology · 2026Article
- Computational Modeling of Cellulose Synthase Heterotrimer Assembly and Identification of Antimicrobial Compounds Targeting Interface Sites inJournal of fungi (Basel, Switzerland) · 2026Article
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- The center of wheat domestication drives diversity ofApplied and environmental microbiology · 2025Article
- Abiotic Factors and Plant Communities Shape the Distribution of Soil Pathogenic Oomycetes in Chinese Grasslands.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The genetic legacy of a global marine invader.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Protists as determinants of the One Health framework.The ISME journal · 2025Review
- Long-distance gene flow and recombination shape the evolutionary history of a maize pathogen.IMA fungus · 2025Article
- A pangenome analysis reveals the center of origin and evolutionary history of Phytophthora infestans and 1c clade species.PloS one · 2025Article
- Genomic profiles ofFrontiers in plant science · 2025Article
- The Good, the Bad, and the Fungus: Insights into the Relationship Between Plants, Fungi, and Oomycetes in Hydroponics.Biology · 2024Review
- The molecular dynamics between reactive oxygen species (ROS), reactive nitrogen species (RNS) and phytohormones in plant's response to biotic stress.Plant cell reports · 2024Review
- Antioxidant and Antifungal Properties of Cinnamon, Cloves,Pathogens (Basel, Switzerland) · 2024Article
- Reconstructing historic and modern potato late blight outbreaks using text analytics.Scientific reports · 2024Article
- Harnessing microbial communities for enhanced plant resilience against diseases.Frontiers in microbiology · 2024Article
- Harnessing Plant's Arsenal: Essential Oils as Promising Tools for Sustainable Management of Potato Late Blight Disease Caused byMolecules (Basel, Switzerland) · 2023Review
- Hiding in plain sight: Genome-wide recombination and a dynamic accessory genome drive diversity inProceedings of the National Academy of Sciences of the United States of America · 2023Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytophthora infestans is a destructive plant pathogen best known for causing the disease that triggered the Irish potato famine and remains the most costly potato pathogen to manage worldwide. Identification of P. infestan's elusive center of origin is critical to understanding the mechanisms of repeated global emergence of this pathogen. There are two competing theories, placing the origin in either South America or in central Mexico, both of which are centers of diversity of Solanum host plants. To test these competing hypotheses, we conducted detailed phylogeographic and approximate Bayesian computation analyses, which are suitable approaches to unraveling complex demographic histories. Our analyses used microsatellite markers and sequences of four nuclear genes sampled from populations in the Andes, Mexico, and elsewhere. To infer the ancestral state, we included the closest known relatives Phytophthora phaseoli, Phytophthora mirabilis, and Phytophthora ipomoeae, as well as the interspecific hybrid Phytophthora andina. We did not find support for an Andean origin of P. infestans; rather, the sequence data suggest a Mexican origin. Our findings support the hypothesis that populations found in the Andes are descendants of the Mexican populations and reconcile previous findings of ancestral variation in the Andes. Although centers of origin are well documented as centers of evolution and diversity for numerous crop plants, the number of plant pathogens with a known geographic origin are limited. This work has important implications for our understanding of the coevolution of hosts and pathogens, as well as the harnessing of plant disease resistance to manage late blight.
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