ReviewNature reviews. Cardiology2014
The vortex--an early predictor of cardiovascular outcome?
Review in Nature reviews. Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03854071 (Development of Novel Physiological CMR Methods in Health and Disease), which is not on this map. Cited by 117 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of Novel Physiological CMR Methods in Health and Disease
Who cites it
117 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Four-dimensional flow cardiovascular magnetic resonance in tetralogy of Fallot: a systematic review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Pooled it
- Effect of the Mitral Valve on the Intra Ventricular Hemodynamics.International journal for numerical methods in biomedical engineering · 2026Article
- Late-systolic to early-diastolic hemodynamic force analysis in ischemic heart disease using vector flow mapping and invasive pressure measurement.Heart and vessels · 2026Article
- Investigating Biventricular Intracardiac Flow Remodeling in Marathon Athletes With 4D Flow Cardiac MRI.Journal of magnetic resonance imaging : JMRI · 2026Article
- Integration of multiple perspectives to understand the left ventricular pressure-volume relationship.Communications medicine · 2026Review
- 4D Flow MRI Characterization of Left Atrial Vortical Flow in Atrial Fibrillation Following Catheter Ablation.Journal of imaging · 2026Article
- Personalized tricuspid valve modeling predicts regurgitation biomechanical repair and double‑orifice flow.Physical and engineering sciences in medicine · 2026Article
- Ultrasound-based haemodynamic force trajectories in a murine model of reversible pressure overload.The Journal of physiology · 2026Article
- Novel Insights from Blood Speckle Imaging for the Assessment of Left Ventricular Flow Dynamics in Adult Patients: A Three-Patient Proof-of-Concept Case Series in the Context of Current Evidence.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion.International journal of engineering science · 2026Article
- Integrated Strain-Flow Analysis for Early Assessment of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.Annals of biomedical engineering · 2026Article
- Development and Initial Validation of the Novel Computational Method for Dynamic Intracardiac Blood Flow Evaluation.Diagnostics (Basel, Switzerland) · 2026Article
- High-Frame-Rate Echocardiography: A New Frontier in Noninvasive Functional Assessment.Journal of clinical medicine · 2026Review
- Experimental and computational models for intracardiac flow analysis with blood speckle imaging.PloS one · 2026Article
- Vortex formation of cardiac bilateral ventricles in fetuses with tetralogy of fallot assessed by blood speckle-tracking echocardiography.BMC pregnancy and childbirth · 2025Article
- Understanding the Transvalvular Gradient in Aortic Stenosis: A Multifaceted Perspective.Journal of clinical medicine · 2025Review
- Longitudinal Intracardiac Right Ventricular Flow Analysis in Infants With Hypoplastic Left Heart Syndrome in Interstage I Using Novel Doppler Velocity Reconstruction.Journal of the American Heart Association · 2025Article
- Reproducibility of the systolic and diastolic energy loss of the left ventricle in vector flow mapping.Journal of echocardiography · 2025Article
- Left atrial energy loss as a novel predictor of mortality and cardiovascular events in chronic kidney disease patients with preserved ejection fraction.BMC cardiovascular disorders · 2025Article
- Impact of mitral valve interventions on left ventricular hemodynamics: Insights into energy loss and flow dynamics.JTCVS open · 2025Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood motion in the heart features vortices that accompany the redirection of jet flows towards the outlet tracks. Vortices have a crucial role in fluid dynamics. The stability of cardiac vorticity is vital to the dynamic balance between rotating blood and myocardial tissue and to the development of cardiac dysfunction. Moreover, vortex dynamics immediately reflect physiological changes to the surrounding system, and can provide early indications of long-term outcome. However, the pathophysiological relevance of cardiac fluid dynamics is still unknown. We postulate that maladaptive intracardiac vortex dynamics might modulate the progressive remodelling of the left ventricle towards heart failure. The evaluation of blood flow presents a new paradigm in cardiac function analysis, with the potential for sensitive risk identification of cardiac abnormalities. Description of cardiac flow patterns after surgery or device therapy provides an intrinsic qualitative evaluation of therapeutic procedures, and could enable early risk stratification of patients vulnerable to adverse cardiac remodelling.
Indexed as
Identifiers
24889521What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.