ArticleJournal of magnetic resonance imaging : JMRI2015
MR diffusion is sensitive to mechanical loading in human intervertebral disks ex vivo.
Article in Journal of magnetic resonance imaging : JMRI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Diagnostic efficiency of intravoxel incoherent motion-based virtual magnetic resonance elastography in pulmonary neoplasms.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Differentiation of salivary gland tumours using diffusion-weighted image-based virtual MR elastography: a pilot study.Dento maxillo facial radiology · 2024Article
- Comparison and optimization of b value combinations for diffusion-weighted imaging in discriminating hepatic fibrosis.Abdominal radiology (New York) · 2024Article
- Applications of Diffusion-Weighted MRI to the Musculoskeletal System.Journal of magnetic resonance imaging : JMRI · 2024Review
- Immediate effect of upright position on lumbar disc using multiposture MRI: Preliminary results.Journal of clinical imaging science · 2024Article
- Acute Physiological Response of Lumbar Intervertebral Discs to High-load Deadlift Exercise.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2021Article
- Spine biomechanical testing methodologies: The controversy of consensus vs scientific evidence.JOR spine · 2021Review
- Review
- A comparative study of diffusion kurtosis imaging and T2* mapping in quantitative detection of lumbar intervertebral disk degeneration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
- Diffusion based MR measurements correlates with age-related changes in human intervertebral disks.Clinical biomechanics (Bristol, Avon) · 2019Article
- Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation.BioResearch open access · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo use T2 and diffusion MR to determine the change in the mechanical function of human disks with increased degenerative state. MATERIALS AND
methodsSpatial changes in T2 and diffusion were quantified in five cadaveric human lumbar disks under compressive loads. Regression models were used to investigate the relationship between the change in MR parameters and the disk's dynamic and viscoelastic properties.
resultsCompressive loading caused a significant reduction in the disk's mean diffusivity ([11.3 versus 9.7].10(-4) .mm(2) /s, P < 0.001) but little change in T2 (P < 0.05). Diffusivity and T2 were correlated with the disk's dynamic (P < 0.01 and P < 0.05) and long-term viscoelastic (P < 0.05 and P < 0.05) stiffness. Diffusivity but not T2, was correlated with its viscoelastic dampening (r(2) = 0.45, P < 0.01) and instantaneous stiffness (r(2) = 0.44, P < 0.05). Nucleus diffusivity was significantly higher than the annulus's (-21% to -4%, P < 0.01). MR-estimated hydration was correlated with the instantaneous viscoelastic stiffness of the nucleus (r(2) = 0.35, P < 0.05) and the dynamic (r(2) = 0.44, P < 0.05) and long-term viscoelastic (r(2) = 0.42, P < 0.05) stiffness in the annulus. T2 correlated with diffusivity at low load (r(2) = 0.66, P < 0.05), but not at high load.
conclusionThe strong correlations between diffusivity and the rheological assessments of disk mechanics suggest that MR might permit quantitative assessment of disk functional status and structural integrity.
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