ArticleJournal of cellular and molecular medicine2014
Phenotypical and ultrastructural features of Oct4-positive cells in the adult mouse lung.
Article in Journal of cellular and molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Telocytes in skeletal muscle: Emerging players in homeostasis and repair/regeneration.Histology and histopathology · 2026Review
- The Role of Telocytes and Telocyte-Derived Exosomes in the Development of Thoracic Aortic Aneurysm.International journal of molecular sciences · 2022Article
- Telocytes: An Emerging Component of Stem Cell Niche Microenvironment.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue.Scientific reports · 2019Article
- Therapeutic roles of telocytes in OVA-induced acute asthma in mice.Journal of cellular and molecular medicine · 2017Article
- Internal associations and dynamic expression of c-kit and nanog genes in ventricular remodelling induced by adriamycin.Experimental and therapeutic medicine · 2016Article
- Isolation, culture, purification and ultrastructural investigation of cardiac telocytes.Molecular medicine reports · 2016Article
- Telopodes of telocytes are influenced in vitro by redox conditions and ageing.Molecular and cellular biochemistry · 2015Article
- The failing human heart is characterized by decreased numbers of telocytes as result of apoptosis and altered extracellular matrix composition.Journal of cellular and molecular medicine · 2015Article
- Skin telocytes versus fibroblasts: two distinct dermal cell populations.Journal of cellular and molecular medicine · 2015Article
- Cardiac telocytes are double positive for CD34/PDGFR-α.Journal of cellular and molecular medicine · 2015Article
- Telocytes in regenerative medicine.Journal of cellular and molecular medicine · 2015Review
- Telocyte dynamics in psoriasis.Journal of cellular and molecular medicine · 2015Article
- Ultrastructure damage of oviduct telocytes in rat model of acute salpingitis.Journal of cellular and molecular medicine · 2015Article
- FIB-SEM tomography of human skin telocytes and their extracellular vesicles.Journal of cellular and molecular medicine · 2015Article
- Cardiac telocytes and fibroblasts in primary culture: different morphologies and immunophenotypes.PloS one · 2015Article
- Dynamics of telopodes (telocyte prolongations) in cell culture depends on extracellular matrix protein.Molecular and cellular biochemistry · 2015Article
- Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels.Histochemistry and cell biology · 2015Article
- Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes.Journal of cellular and molecular medicine · 2014Article
- Comparative proteomic analysis of human lung telocytes with fibroblasts.Journal of cellular and molecular medicine · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Octamer binding trascription factor 4 (Oct4) is a transcription factor of POU family specifically expressed in embryonic stem cells (ESCs). A role for maintaining pluripotency and self-renewal of ESCs is assigned to Oct4 as a pluripotency marker. Oct4 can also be detected in adult stem cells such as bone marrow-derived mesenchymal stem cells. Several studies suggest a role for Oct4 in sustaining self-renewal capacity of adult stem cells. However, Oct4 gene ablation in adult stem cells revealed no abnormalities in tissue turnover or regenerative capacity. In the present study we have conspicuously found pulmonary Oct4-positive cells closely resembling the morphology of telocytes (TCs). These cells were found in the perivascular and peribronchial areas and their presence and location were confirmed by electron microscopy. Moreover, we have used Oct4-GFP transgenic mice which revealed a similar localization of the Oct4-GFP signal. We also found that Oct4 co-localized with several described TC markers such as vimentin, Sca-1, platelet-derived growth factor receptor-beta C-kit and VEGF. By flow cytometry analyses carried out with Oct4-GFP reporter mice, we described a population of EpCAM(neg) /CD45(neg) /Oct4-GFP(pos) that in culture displayed TC features. These results were supported by qRT-PCR with mRNA isolated from lungs by using laser capture microdissection. In addition, Oct4-positive cells were found to express Nanog and Klf4 mRNA. It is concluded for the first time that TCs in adult lung mouse tissue comprise Oct4-positive cells, which express pluripotency-related genes and represent therefore a population of adult stem cells which might contribute to lung regeneration.
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