Evidence map›Paper›PMID 24889153›Full record

ReviewJournal of peptide science : an official publication of the European Peptide Society2014

Exploitation of viral properties for intracellular delivery.

Stefania Galdiero, Annarita Falanga, Mariateresa Vitiello, Paolo Grieco, Michele Caraglia, Giancarlo Morelli, Massimiliano Galdiero

Abstract readReview
In one paragraph

Review in Journal of peptide science : an official publication of the European Peptide Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Designed Multifunctional Peptides for Intracellular Targets.Antibiotics (Basel, Switzerland) · 2022
    Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Membranotropic peptides mediating viral entry.Peptide science (Hoboken, N.J.) · 2018
    Review
  7. Article
  8. Peptide-Based Drugs and Drug Delivery Systems.Molecules (Basel, Switzerland) · 2017
    Article
  9. Article
  10. Review
  11. International journal of nanomedicine · 2017
    Article
  12. Article
  13. Membranotropic Cell Penetrating Peptides: The Outstanding Journey.International journal of molecular sciences · 2015
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefania GaldieroDepartment of Pharmacy, University of Naples "Federico II", Via Mezzocannone 16, and Via Domenico Montesano 49, 80100, Napoli, Italy; Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples "Federico II", Via Mezzocannone 16, 80134, Napoli, Italy; Istituto di Biostrutture e Bioimmagini - CNR, Via Mezzocannone 16, 80134, Napoli, Italy; DFM Scarl, Via Mezzocannone 16, 80134, Napoli, Italy.
Annarita Falanga
Mariateresa Vitiello
Paolo Grieco
Michele Caraglia
Giancarlo Morelli
Massimiliano Galdiero

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanotechnology is an expanding area of study with potentially pivotal applications in a discipline as medicine where new biomedical active molecules or strategies are continuously developing. One of the principal drawbacks for the application of new therapies is the difficulty to cross membranes that represent the main physiological barrier in our body and in all living cells. Membranes are selectively permeable and allow the selective internalization of substances; generally, they form a highly impermeable barrier to most polar and charged molecules, and represent an obstacle for drug delivery, limiting absorption to specific routes and mechanisms. Viruses provide attracting suggestions for the development of targeted drug carriers as they have evolved naturally to deliver their genomes to host cells with high fidelity. A detailed understanding of virus structure and their mechanisms of entry into mammalian cells will facilitate the development and analysis of virus-based materials for medical applications.

Indexed as

AnimalsCapsidCell MembraneCell-Penetrating PeptidesDrug Delivery SystemsHumansNanoparticlesPeptide FragmentsViral Fusion ProteinsVirus InternalizationCell-Penetrating PeptidesPeptide FragmentsViral Fusion Proteinsdeliverynanoparticlepeptidevirus

Identifiers

PMID24889153
PMCPMC7168031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.