Evidence map›Paper›PMID 24888842›Full record

ArticleJournal of pediatric surgery2014

Intestinal alkaline phosphatase is protective to the preterm rat pup intestine.

Nathan P Heinzerling, Jennifer L Liedel, Scott R Welak, Katherine Fredrich, Ben E Biesterveld, Kirkwood A Pritchard, David M Gourlay

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nathan P HeinzerlingMedical College of Wisconsin, Milwaukee, WI 53226, USA.
Jennifer L LiedelDivision of Neonatology, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA; Division of Critical Care, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA.
Scott R WelakDivision of Neonatology, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA.
Katherine FredrichDivision of Pediatric Surgery, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI 53226, USA.
Ben E BiesterveldMedical College of Wisconsin, Milwaukee, WI 53226, USA.
Kirkwood A PritchardDivision of Pediatric Surgery, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI 53226, USA.
David M GourlayDivision of Pediatric Surgery, Medical College of Wisconsin, Children's Hospital of Wisconsin, Children's Research Institute, Milwaukee, WI 53226, USA. Electronic address: dgourlay@chw.org.
Medical College of Wisconsin · US

Funding

Clincal and Translational Science AwardUL1TR000055 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$11.3M
Biophysics of HDL DysfunctionR01HL112270 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI PRITCHARD, KIRKWOOD ARTHUR, SORCI-THOMAS, MARY G · 2012 to 2015
$2.5M
NCATS NIH HHS UL1 TR000055NHLBI NIH HHS R01 HL112270
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) is the most common surgical emergency in neonates, with a mortality rate between 10 and 50%. The onset of necrotizing enterocolitis is highly variable and associated with numerous risk factors. Prior research has shown that enteral supplementation with intestinal alkaline phosphatase (IAP) decreases the severity of NEC. The aim of this study is to investigate whether IAP is protective to the preterm intestine in the presence of formula feeding and in the absence of NEC.

methodsPreterm rat pups were fed formula with or without supplementation with IAP, and intestine was obtained on day of life 3 for analysis of IAP activity, mRNA expression of TNFα, IL-6 and iNOS and permeability and cytokine expression after LPS exposure.

resultsThere was no difference in the absolute and intestine specific alkaline phosphatase activity in both groups. Rat pups fed IAP had decreased mRNA expression of the inflammatory cytokines TNFα, IL-6 and iNOS. Pups supplemented with IAP had decreased permeability and inflammatory cytokine expression after exposure to LPS ex vivo when compared to formula fed controls.

conclusionsOur results support that IAP is beneficial to preterm intestine and decreases intestinal injury and inflammation caused by LPS.

Indexed as

Administration, OralAlkaline PhosphataseAnimalsAnimals, NewbornCytokinesDisease Models, AnimalEnterocolitis, NecrotizingGene Expression Regulation, DevelopmentalIntestinal MucosaRatsRats, Sprague-DawleyReal-Time Polymerase Chain ReactionRNA, MessengerAlkaline PhosphataseCytokinesRNA, MessengerIntestinal alkaline phosphataseLipopolysaccharideNecrotizing enterocolitisToll like receptor 4

Identifiers

PMID24888842
PMCPMC4130394
OpenAlexW1966530004

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.