Trial reportJournal of clinical periodontology2014
Comparing clinical attachment level and pocket depth for predicting periodontal disease progression in healthy sites of patients with chronic periodontitis using multi-state Markov models.
Trial report in Journal of clinical periodontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Prevalence of periodontitis in people clinically diagnosed with diabetes mellitus: a meta-analysis of epidemiologic studies.Acta diabetologica · 2021Pooled it
- A systematic review and meta-analysis on the effects of crown lengthening on adjacent and non-adjacent sites.Clinical oral investigations · 2017Pooled it
- Trial
- Comparative Analysis of Oral Microbiome in Indian Type 2 Diabetes Mellitus (T2DM) and Periodontitis Cohorts.Diseases (Basel, Switzerland) · 2026Article
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- Association between periodontitis and rupture of saccular intracranial aneurysms: a multicenter cross-sectional study.Neurosurgical review · 2025Article
- A monotone single index model for spatially referenced multistate current status data.Biometrics · 2025Article
- Periodontal Probing Depth Trajectory in 10 Years of Follow-Up as Associated With Tooth Loss.Journal of clinical periodontology · 2025Article
- Changes in MMP-9, T-SOD and SIRT-1 levels after non-surgical periodontal treatment.BMC oral health · 2025Article
- Assessment of Salivary MMP-8 and IL-1β for the Diagnosis of Periodontal Diseases in Pakistani Population.European journal of dentistry · 2024Article
- Modelling the national economic burden of non-surgical periodontal management in specialist clinics in Malaysia using a markov model.BMC oral health · 2024Article
- Pseudo-value regression of clustered multistate current status data with informative cluster sizes.Statistical methods in medical research · 2023Article
- Periodontal Disease and Smoking: Systematic Review.Journal of pharmacy & bioallied sciences · 2023Article
- Periodontal Diseases and Diabetes Mellitus: A Systematic Review.Journal of pharmacy & bioallied sciences · 2023Article
- Salivary MMP-9 Levels in Chronic Periodontitis Patients with Type-II Diabetes Mellitus.Molecules (Basel, Switzerland) · 2022Article
- Article
- Association between rheumatoid arthritis and periodontitis in an adult population - A cross sectional study.Journal of clinical and experimental dentistry · 2021Article
- The Chairside Periodontal Diagnostic Toolkit: Past, Present, and Future.Diagnostics (Basel, Switzerland) · 2021Review
- Comparative Effects of E-Cigarette Aerosol on Periodontium of Periodontitis Patients.Frontiers in oral health · 2021Article
- Validation of Self-reported Periodontal Disease Status Among Subjects Seeking Dental Treatment in a Dental School.Journal of pharmacy & bioallied sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
aimTo understand degeneration of healthy sites and identify factors associated with disease progression in patients with chronic periodontitis. MATERIAL AND
methodsData on healthy sites from 163 American and Swedish subjects were analysed using two-three-state (health, gingivitis, chronic periodontitis) Markov models based on bleeding on probing (BOP), and either clinical attachment level (CAL) + BOP or pocket depth (PD) + BOP.
resultsIn 2 years, 10% (CAL + BOP) and 3% (PD + BOP) of healthy sites developed chronic periodontitis. On average, healthy sites remained healthy for 32 months before transiting in both models. Most transitions (87-97%) from health were to the gingivitis state. The expected duration of the gingivitis lesion was 4-5 months and sites recovered with a high probability (96-98%). Disease severity as measured by number of sites with CAL/PD > 4 mm at baseline and smoking, were associated with fast progression from health to chronic periodontitis within 6 months as were gingival redness in the PD + BOP model only. With age, the rate of disease progression to gingivitis decreased.
conclusionTransition probabilities for gingivitis and chronic periodontitis were higher with CAL + BOP than with PD + BOP. Smoking and disease severity were significant predictors for fast progression.
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