ArticleEnvironmental science and pollution research international2014
Biochemical and standard toxic effects of acetaminophen on the macrophyte species Lemna minor and Lemna gibba.
Article in Environmental science and pollution research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Interaction of cyanobacteria and microplastics polystyrene spiked with pharmaceutical drug-paracetamol.Scientific reports · 2025Article
- Advancing conventional guidelines in phytotoxicity studies assessing toxicant's impact on seedling morphology and anatomy.Scientific reports · 2025Article
- Impact of Caffeine on Aquatic Ecosystems: Assessing Trophic-Level Biological Responses.Journal of xenobiotics · 2025Article
- Chronic low doseFrontiers in plant science · 2025Article
- Delineating acetaminophen biodegradation kinetics and metabolomics using bacterial community.Biodegradation · 2024Article
- Assessment of ecotoxicological effects of Fojo coal mine waste elutriate in aquatic species (Douro Coalfield, North Portugal).Frontiers in toxicology · 2024Article
- Detection of Acetaminophen in Groundwater by Laccase-Based Amperometric Biosensors Using MoSSensors (Basel, Switzerland) · 2023Article
- Accumulation of Proline in Plants under Contaminated Soils-Are We on the Same Page?Antioxidants (Basel, Switzerland) · 2023Review
- A review on the degradation of acetaminophen by advanced oxidation process: pathway, by-products, biotoxicity, and density functional theory calculation.RSC advances · 2022Review
- Effect of eight common Brazilian drugs on Lemna minor and Salvinia auriculata growth.Environmental science and pollution research international · 2021Article
- Assessing potential aquatic toxicity of airport runoff using physicochemical parameters and Lemna gibba and Aliivibrio fischeri bioassays.Environmental science and pollution research international · 2020Article
- Toxicity of NSAID drug (paracetamol) to nontarget organism-Nostoc muscorum.Environmental science and pollution research international · 2020Article
- Effects of commonly used therapeutic drugs, paracetamol, and acetylsalicylic acid, on key physiological traits of the sea snail Gibbula umbilicalis.Environmental science and pollution research international · 2019Article
- Effects of acetaminophen in oxidative stress and neurotoxicity biomarkers of the gastropod Phorcus lineatus.Environmental science and pollution research international · 2019Article
- Acute ecotoxicological effects of salicylic acid on the Polychaeta species Hediste diversicolor: evidences of low to moderate pro-oxidative effects.Environmental science and pollution research international · 2019Article
- Assessment of biochemical alterations in the neotropical fish species Phalloceros harpagos after acute and chronic exposure to the drugs paracetamol and propranolol.Environmental science and pollution research international · 2018Article
- Preliminary evaluation of Diopatra neapolitana regenerative capacity as a biomarker for paracetamol exposure.Environmental science and pollution research international · 2015Article
- Biochemical effects of the pharmaceutical drug paracetamol on Anguilla anguilla.Environmental science and pollution research international · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetaminophen is globally one of the most prescribed drugs due to its antipyretic and analgesic properties. However, it is highly toxic when the dosage surpasses the detoxification capability of an exposed organism, with involvement of an already described oxidative stress pathway. To address the issue of the ecotoxicity of acetaminophen, we performed acute exposures of two aquatic plant species, Lemna gibba and Lemna minor, to this compound. The selected biomarkers were number of fronds, biomass, chlorophyll content, lipid peroxidation (TBARS assay), and proline content. Our results showed marked differences between the two species. Acetaminophen caused a significant decrease in the number of fronds (EC50 = 446.6 mg/L), and the establishment of a dose-dependent peroxidative damage in L. minor, but not in L. gibba. No effects were reported in both species for the indicative parameters chlorophyll content and total biomass. However, the proline content in L. gibba was substantially reduced. The overall conclusions point to the occurrence of an oxidative stress scenario more prominent for L. minor. However, the mechanisms that allowed L. gibba to cope with acetaminophen exposure were distinct from those reported for L. minor, with the likely involvement of proline as antioxidant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.