Evidence map›Paper›PMID 24888584›Full record

ArticleGenes & development2014

'Doubling down' on the autophagy pathway to suppress tumor growth.

Andrew M Leidal, Jayanta Debnath

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review.Journal of experimental & clinical cancer research : CR · 2019
    Review
  3. Review
  4. Autophagic Regulation of p62 is Critical for Cancer Therapy.International journal of molecular sciences · 2018
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Andrew M LeidalDepartment of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.
Jayanta DebnathDepartment of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.

Funding

Autophagy in Adhesion and MetastasisR01CA126792 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jayanta Debnath · 2009 to 2026
$5.3M
NCI NIH HHS CA126792-S1NCI NIH HHS R01 CA126792NCI NIH HHS R01CA126792
6 · The paper itself

Abstract

In this issue of Genes & Development, Wei and colleagues (pp. 1204-1216) use elegant genetic approaches to simultaneously delete the essential autophagy gene FIP200 (FAK family-interacting protein of 200 kDa) and the signaling adaptor p62/SQSTM1 within established murine tumors, which reveals an unexpected synergism between the autophagy pathway and p62 in driving tumor growth. Intriguingly, these observations suggest that the combined targeting of autophagy and p62 may serve as an effective approach to treat specific cancers.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAutophagyBreast NeoplasmsFemaleHeat-Shock ProteinsHumansSequestosome-1 ProteinAdaptor Proteins, Signal TransducingHeat-Shock ProteinsSequestosome-1 ProteinSqstm1 protein, mouseautophagymouse modelsp62tumor growth

Identifiers

PMID24888584
PMCPMC4052759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.