ArticleAngewandte Chemie (International ed. in English)2014
In vivo imaging of mouse tumors by a lipidated cathepsin S substrate.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Engineering Cathepsin S Selective Chemical Probes and Antibody-Drug Conjugates through Substrate Profiling with Unnatural Amino Acids.Journal of medicinal chemistry · 2026Article
- Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery.Molecular imaging and biology · 2023Review
- Molecular probes for selective detection of cysteine cathepsins.Organic & biomolecular chemistry · 2021Review
- The Tumor Proteolytic Landscape: A Challenging Frontier in Cancer Diagnosis and Therapy.International journal of molecular sciences · 2021Review
- Targeting Cartilage Degradation in Osteoarthritis.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Peptidyl Activity-Based Probes for Imaging Serine Proteases.Frontiers in chemistry · 2021Review
- Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model.EJNMMI research · 2020Article
- Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples.Chemical science · 2019Article
- Review
- A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging.Acta pharmaceutica Sinica. B · 2018Article
- Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.Chemical science · 2018Article
- Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors.Bioconjugate chemistry · 2017Article
- Imaging the Tumor Microenvironment.Advances in experimental medicine and biology · 2017Review
- Non-invasiveTheranostics · 2017Article
- Rational design of asymmetric red fluorescent probes for live cell imaging with high AIE effects and large two-photon absorption cross sections using tunable terminal groups.Chemical science · 2016Article
- A dual-functional lanthanide nanoprobe for both living cell imaging and ICP-MS quantification of active protease.Chemical science · 2016Article
- A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application.Cell chemical biology · 2016Review
- Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery.ACS chemical biology · 2015Article
- Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.Journal of the American Chemical Society · 2015Article
- Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins.Chemistry & biology · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis and evaluation of two cathepsin S-specific probes is described. For long-term retention of the probe at the target site and a high signal-to-noise ratio, we introduced a lipidation approach via the simple attachment of palmitoic acid to the reporter. After cathepsin S-specific cleavage in cultured cells and in a grafted tumor mouse model, fluorescence increased owing to dequenching and we observed an intracellular accumulation of the fluorescence in the target tissue. The lipidated probe provided a prolonged and strongly fluorescent signal in tumors when compared to the very similar non-lipidated probe, demonstrating that non-invasive tumor identification is feasable. The homing principle by probe lipidation might also work for selective administration of cytotoxic compounds to specifically reduce tumor mass.
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Registered trials
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