Evidence map›Paper›PMID 24888461›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2014

Venous thromboembolic prophylaxis after a hepatic resection: patterns of care among liver surgeons.

Matthew J Weiss, Yuhree Kim, Aslam Ejaz, Gaya Spolverato, Elliott R Haut, Kenzo Hirose, Christopher L Wolfgang, Michael A Choti, Timothy M Pawlik

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02597218 (Incidence of Venous Thromboembolic Disease and Portal Vein Thrombosis After Hepatectomy in a High-volume Center. A Cohort Study.), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02597218 unknown statusnot on this mapstarted 2015, after this paper: background citation

Incidence of Venous Thromboembolic Disease and Portal Vein Thrombosis After Hepatectomy in a High-volume Center. A Cohort Study.

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2015 to 2020Enrolled350ConditionsPulmonary Embolism, Venous Thrombosis, Portal Thrombosis
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Safety of postdischarge extended venous thromboembolism prophylaxis after hepatopancreatobiliary surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Association Between Operative Approach and Venous Thromboembolism Rate Following Hepatectomy: a Propensity-Matched Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Article
  11. Development and validation of a risk calculator for post-discharge venous thromboembolism following hepatectomy for malignancy.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2021
    Article
  12. Article
  13. Article
  14. Dabigatran (Pradaxa) Is Safe for Extended Venous Thromboembolism Prophylaxis After Surgery for Pancreatic Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
    Article
  15. Review
  16. Article
  17. Patient Adherence and Experience with Extended Use of Prophylactic Low-Molecular-Weight Heparin Following Pancreas and Liver Resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016
    Article
  18. Venous Thromboembolism Prophylaxis in Liver Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Matthew J WeissDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuhree Kim
Aslam Ejaz
Gaya Spolverato
Elliott R Haut
Kenzo Hirose
Christopher L Wolfgang
Michael A Choti
Timothy M Pawlik
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNo consensus exists for post-hepatectomy venous thromboembolic (VTE) prophylaxis. Factors impacting VTE prophylaxis patterns among hepato-pancreato-biliary (HPB) surgeons were defined.

methodSurgeons were invited to complete a web-based survey on VTE prophylaxis. The impact of physician and clinical factors was analysed.

resultsTwo hundred responses were received. Most respondents were male (91%) and practiced at academic centres (88%) in the United States (80%). Surgical training varied: HPB (24%), transplantation (24%), surgical oncology (34%), HPB/transplantation (13%), or no specialty (5%). Respondents estimated VTE risk was higher after major (6%) versus minor (3%) resections. Although 98% use VTE prophylaxis, there was considerable variability: sequential compression devices (SCD) (91%), unfractionated heparin Q12h (31%) and Q8h (32%), and low-molecular weight heparin (39%). While 88% noted VTE prophylaxis was not impacted by operative indication, 16% stated major resections reduced their VTE prophylaxis. Factors associated with the decreased use of pharmacologic prophylaxis included: elevated international normalized ratio (INR) (74%), thrombocytopaenia (63%), liver insufficiency (58%), large EBL (46%) and complications (8%). Forty-seven per cent of respondents wait until ≥post-operative day 1 (POD1) and 35% hold pharmacologic VTE prophylaxis until no signs of coagulopathy. A minority (14%) discharge patients on pharmacologic prophylaxis. While 81% have institutional VTE guidelines, 79% believe hepatectomy-specific guidelines would be helpful.

conclusionThere is considerable variation regarding VTE prophylaxis among liver surgeons. While most HPB surgeons employ VTE prophylaxis, the methods, timing and purported contraindications differ significantly.

Indexed as

ConsensusDrug Administration ScheduleFemaleFibrinolytic AgentsGuideline AdherenceHealth Care SurveysHemorrhageHepatectomyHumansInternetMalePractice Guidelines as TopicPractice Patterns, Physicians'Risk AssessmentRisk FactorsSurveys and QuestionnairesFibrinolytic Agents

Identifiers

PMID24888461
PMCPMC4238855
OpenAlexW2079142915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.