SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2015
Significant elevations of serum lipase not caused by pancreatitis: a systematic review.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Prevalence and prognosis of increased pancreatic enzymes in patients with COVID-19: A systematic review and meta-analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Pooled it
- Hyperlipasemia and Potential Pancreatic Injury Patterns in COVID-19: A Marker of Severity or Innocent Bystander?Gastroenterology · 2021Pooled it
- Pancreatic Hyperenzymemia in Inflammatory Bowel Disease: Clinical Characterization and Outcomes from the European PANDORA Registry.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Article
- Development of a Donor-Based Predictive Model for Pancreas Non-Utilization Among Deceased Donor Transplants in the US.Clinical transplantation · 2026Article
- Case Report: Duodenal neoplasm-induced panniculitis.Frontiers in medicine · 2026Article
- Article
- Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis.World journal of gastroenterology · 2025Article
- Correlation of Modified CT Severity Index (MCTSI) and serum lipase levels in assessing acute pancreatitis severity: a prospective cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
- Immune checkpoint inhibitor-induced pancreatic enzyme elevation in melanoma patients: Incidence, management and therapy-A multicentre analysis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- Paraneoplastic Effects of Lung Adenocarcinoma Causing Persistently Elevated Lipase, Amylase, and CA 19-9.ACG case reports journal · 2025Article
- Discordance Between Radiological and Clinical Findings Among Patients Presenting With Elevated Lipase and Abdominal Pain.Clinical and translational gastroenterology · 2025Article
- Hematological Parameter-Derived Inflammatory Scores in Non-Pancreatic Hyperlipasemia (NPHL)-The Prognosis Lies in the Blood.Biomedicines · 2025Article
- Clinical Evaluation of Patients with Elevated Serum Lipase.Digestive diseases and sciences · 2025Review
- Co-Infection of Chicken Infectious Anemia Virus and Fowl Adenovirus Serotype E8b Increases Mortality in Chickens.Viruses · 2025Article
- Serum hsa-miR-22-3p, hsa-miR-885-5p, Lipase-to-Amylase Ratio, C-Reactive Protein, CA19-9, and Neutrophil-to-Lymphocyte Ratio as Prognostic Factors in Advanced Pancreatic Ductal Adenocarcinoma.Current issues in molecular biology · 2025Article
- Amylase and lipase levels in the metabolic syndrome and type 2 diabetes: A longitudinal study in rhesus monkeys.Physiological reports · 2024Article
- Prospective Validation of a Prediction Model for the Diagnosis of Acute Pancreatitis.JAMA network open · 2024Article
- Non-pancreatic hyperlipasemia: A puzzling clinical entity.World journal of gastroenterology · 2024Observational
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany authors advocate lipase as the preferred serological test for the diagnosis of pancreatitis and a cut-off level of three or more times the upper limit of normal (ULN) is often quoted. The literature contains no systematic review that explores alternative causes of a lipase level over three times as high as the ULN. Such a review was therefore the objective of this study.
methodsThe EMBASE and MEDLINE databases (1985 to August 2013) were searched for all eligible articles. Predetermined data were extracted and independently analysed by two reviewers.
resultsIn total, data from 58 studies were included in the final analysis. The following causes other than pancreatitis of lipase levels exceeding three times the ULN were found: reduced clearance of lipase caused by renal impairment or macrolipase formation; other hepatobiliary, gastroduodenal, intestinal and neoplastic causes; critical illness, including neurosurgical pathology; alternative pancreatic diagnoses, such as non-pathological pancreatic hyperenzymaemia, and miscellaneous causes such as diabetes, drugs and infections.
conclusionsA series of differential diagnoses for significant serum lipase elevations (i.e. exceeding three times the ULN) has been provided by this study. Clinicians should utilize this knowledge in the interpretation and management of patients who have lipase levels over three times as high as the ULN, remaining vigilant for an alternative diagnosis to pancreatitis. The medical officer should be aware of the possibility of incorrect diagnosis in the asymptomatic patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.