Trial reportJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society2014
Efficient and reliable characterization of the corticospinal system using transcranial magnetic stimulation.
Trial report in Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- On the reliability of motor evoked potentials in hand muscles of healthy adults: a systematic review.Frontiers in human neuroscience · 2023Pooled it
- Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review.Journal of psychiatry & neuroscience : JPNPooled it
- Optimizing transcutaneous spinal stimulation: excitability of evoked spinal reflexes is dependent on electrode montage.Journal of neuroengineering and rehabilitation · 2025Trial
- Trial
- Characterising the Diffusion Functional Signature of Negative BOLD With Interleaved TMS-fMRI in the Human Brain.Human brain mapping · 2026Article
- A Brief Mindfulness Intervention for Pain Management in Fibromyalgia: A Single-arm Open-Label Study.Restorative neurology and neuroscience · 2026Article
- Heterogeneous Recruitment Curve Responses to Anodal Transcranial Direct Current Stimulation in Children With Unilateral Spastic Cerebral Palsy.Neurorehabilitation and neural repair · 2026Article
- Rapid Multimuscle Cortical Mapping of the Upper Limb: Activity Reveals Intralimb Gradients.The European journal of neuroscience · 2026Article
- Transient effects in corticospinal and reticulospinal tract excitability induced by motor skill and isometric resistance training.Brain research · 2026Article
- Long-interval intracortical inhibition is similar in people with and without amyotrophic lateral sclerosis.Brain communications · 2026Article
- MEPs elicited by multidirectional rotational-field TMS show marked differences compared to unidirectional Figure-of-8 and H7 coils.PloS one · 2026Article
- Differences in Hebbian stimulation effects between biceps and triceps brachii in humans.Journal of neurophysiology · 2025Article
- Relating cortical morphology, corticospinal excitability, corticomotor representation, and quadriceps strength after anterior cruciate ligament injury.Experimental brain research · 2025Article
- The spatio-functional cortical representation of muscles innervated by the accessory nerve using nTMS.Clinical neurophysiology practice · 2025Article
- Neural pathway activation in the subthalamic region depends on stimulation polarity.Brain communications · 2025Article
- Differential induction of Parieto-motor plasticity in writer's cramp and cervical dystonia.Neurobiology of disease · 2024Article
- A 3D-Printed helmet for precise and repeatable neuromodulation targeting in awake non-human primates.Heliyon · 2024Article
- Corticospinal excitability at rest outside of a task does not differ from task intertrial intervals in healthy adults.Experimental brain research · 2024Article
- Optimizing Transcutaneous Spinal Stimulation: Excitability of Evoked Spinal Reflexes is Dependent on Electrode Montage.Research square · 2024Article
- Reliability of a method to assess corticomotor excitability of lower limb muscles using a normalized EMG motor thresholding procedure.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeThe purpose of this study is to develop a method to reliably characterize multiple features of the corticospinal system in a more efficient manner than typically done in transcranial magnetic stimulation studies.
methodsForty transcranial magnetic stimulation pulses of varying intensity were given over the first dorsal interosseous motor hot spot in 10 healthy adults. The first dorsal interosseous motor-evoked potential size was recorded during rest and activation to create recruitment curves. The Boltzmann sigmoidal function was fit to the data, and parameters relating to maximal motor-evoked potential size, curve slope, and stimulus intensity leading to half-maximal motor-evoked potential size were computed from the curve fit.
resultsGood to excellent test-retest reliability was found for all corticospinal parameters at rest and during activation with 40 transcranial magnetic stimulation pulses.
conclusionsThrough the use of curve fitting, important features of the corticospinal system can be determined with fewer stimuli than typically used for the same information. Determining the recruitment curve provides a basis to understand the state of the corticospinal system and select subject-specific parameters for transcranial magnetic stimulation testing quickly and without unnecessary exposure to magnetic stimulation. This method can be useful in individuals who have difficulty in maintaining stillness, including children and patients with motor disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.