Evidence map›Paper›PMID 24887553›Full record

ArticleNature communications2014

Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink.

Falguni Pati, Jinah Jang, Dong-Heon Ha, Sung Won Kim, Jong-Won Rhie, Jin-Hyung Shim, Deok-Ho Kim, Dong-Woo Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 677 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
677citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

677 citing papers in PubMed, 1 synthesis or guideline pooled it.

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617 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Falguni Pati1] Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam ro, Nam-gu, Pohang, Kyungbuk 790-784, South Korea [2].
Jinah Jang1] Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 77 Cheongam ro, Nam-gu, Pohang, Kyungbuk 790-784, South Korea [2] Department of Bioengineering, University of Washington, Seattle, Waltham 98195, USA [3].
Dong-Heon HaDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam ro, Nam-gu, Pohang, Kyungbuk 790-784, South Korea.
Sung Won Kim1] Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-710, South Korea [2] Department of Biomedical Science, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, South Korea.
Jong-Won RhieDepartment of Plastic Surgery, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, South Korea.
Jin-Hyung ShimDepartment of Mechanical Engineering, Korea Polytechnic University, 2121 Jeongwang-dong, Siheungsi, Gyeonggi-do 429-793, South Korea.
Deok-Ho Kim1] Department of Bioengineering, University of Washington, Seattle, Waltham 98195, USA [2] Center for Cardiovascular Biology, University of Washington, Seattle, Waltham 98109, USA [3] Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
Dong-Woo ChoDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam ro, Nam-gu, Pohang, Kyungbuk 790-784, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to print and pattern all the components that make up a tissue (cells and matrix materials) in three dimensions to generate structures similar to tissues is an exciting prospect of bioprinting. However, the majority of the matrix materials used so far for bioprinting cannot represent the complexity of natural extracellular matrix (ECM) and thus are unable to reconstitute the intrinsic cellular morphologies and functions. Here, we develop a method for the bioprinting of cell-laden constructs with novel decellularized extracellular matrix (dECM) bioink capable of providing an optimized microenvironment conducive to the growth of three-dimensional structured tissue. We show the versatility and flexibility of the developed bioprinting process using tissue-specific dECM bioinks, including adipose, cartilage and heart tissues, capable of providing crucial cues for cells engraftment, survival and long-term function. We achieve high cell viability and functionality of the printed dECM structures using our bioprinting method.

Indexed as

Extracellular MatrixPrinting, Three-DimensionalTissue ScaffoldsAdipose TissueAnimalsBioprintingCartilageHeartHumansHyaline CartilageInkMesenchymal Stem CellsStem CellsSwineTissue Engineering

Identifiers

PMID24887553
PMCPMC4059935

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.