ArticleJournal of physiological anthropology2014
Association between the melanopsin gene polymorphism OPN4*Ile394Thr and sleep/wake timing in Japanese university students.
Article in Journal of physiological anthropology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Human melanopsin (OPN4) gene polymorphisms: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Review on age-related differences in non-visual effects of light: melatonin suppression, circadian phase shift and pupillary light reflex in children to older adults.Journal of physiological anthropology · 2023Review
- Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer's disease and longevity in an Italian population.GeroScience · 2022Article
- Is the use of high correlated color temperature light at night related to delay of sleep timing in university students? A cross-country study in Japan and China.Journal of physiological anthropology · 2021Article
- Review
- Association of P10L Polymorphism in Melanopsin Gene with Chronic Insomnia in Mexicans.International journal of environmental research and public health · 2021Article
- A review of the studies on nonvisual lighting effects in the field of physiological anthropology.Journal of physiological anthropology · 2019Review
- Article
- Functional characterisation of naturally occurring mutations in human melanopsin.Cellular and molecular life sciences : CMLS · 2018Article
- Defining the impact of melanopsin missense polymorphisms using in vivo functional rescue.Human molecular genetics · 2018Article
- Impact of seasons on an individual's chronotype: current perspectives.Nature and science of sleep · 2018Review
- Article
- Using Flickering Light to Enhance Nonimage-Forming Visual Stimulation in Humans.Investigative ophthalmology & visual science · 2015Article
- Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn our previous studies, we found that the Ile394Thr SNP in the melanopsin gene (OPN4) was functionally associated with the pupillary light reflex. This indicates the possibility that OPN4*Ile394Thr is associated with other non-image forming responses. The aim of this study was therefore to determine whether OPN4*Ile394Thr is associated with sleep/wake timing.
methodsA total of 348 healthy Japanese university students participated in this study. Scalp hair was used to genotype the Ile394Thr SNP of OPN4. Sleep habits, including bedtime, wake time and sleep duration, were assessed separately for weekdays and weekends. A total of 328 samples, including 223 samples with TT genotype, 91 with TC genotype and 14 with CC genotype, were used for statistical analysis. No significant difference in age or male/female distribution was found among the three genotype groups.
resultsThere was no significant difference in circadian preference among the genotype groups. During weekdays, bedtime, wake time and midpoint of sleep for CC subjects were significantly later than those for TT and TC subjects. However, there was no difference between TT and TC subjects in any of their sleep habits. During weekends, bedtime of CC subjects was significantly later than those of TT and TC subjects, and the midpoint of sleep of CC subjects was significantly later than that of TC subjects.
conclusionsOur findings demonstrated that OPN4*Ile394Thr is associated with sleep/wake timing. We also found that the sleep/wake timing of subjects with the CC genotype was later than that of subjects with the TT or TC genotype.
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