ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2014
Synthesis and evaluation of nitroxide-based oligoradicals for low-temperature dynamic nuclear polarization in solid state NMR.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- High-frequency high-power DNP/EPR spectrometer operating at 7 T magnetic field.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024Article
- Rational Design of Persistent Phosphorus-Centered Singlet Tetraradicals and Their Use in Small-Molecule Activation.Journal of the American Chemical Society · 2023Article
- Polarizing agents for efficient high field DNP solid-state NMR spectroscopy under magic-angle spinning: from design principles to formulation strategies.Chemical science · 2023Review
- A Comparative Study of Nitroxide-Based Biradicals for Dynamic Nuclear Polarization in Cellular Environments.Chembiochem : a European journal of chemical biology · 2022Article
- Nitroxide-based triradical dopants for efficient low-temperature dynamic nuclear polarization in aqueous solutions over a broad pH range.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Enhanced spatial resolution in magnetic resonance imaging by dynamic nuclear polarization at 5 K.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Targeted DNP for biomolecular solid-state NMR.Chemical science · 2021Review
- Succinyl-DOTOPA: An effective triradical dopant for low-temperature dynamic nuclear polarization with high solubility in aqueous solvent mixtures at neutral pH.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Temperature-Dependent Nuclear Spin Relaxation Due to Paramagnetic Dopants Below 30 K: Relevance to DNP-Enhanced Magnetic Resonance Imaging.The journal of physical chemistry. B · 2018Article
- Maximizing NMR signal per unit time by facilitating the e-e-n cross effect DNP rate.Physical chemistry chemical physics : PCCP · 2018Article
- Tuning nuclear depolarization under MAS by electron TPhysical chemistry chemical physics : PCCP · 2018Article
- Computationally Assisted Design of Polarizing Agents for Dynamic Nuclear Polarization Enhanced NMR: The AsymPol Family.Journal of the American Chemical Society · 2018Article
- Verdazyl-ribose: A new radical for solid-state dynamic nuclear polarization at high magnetic field.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- A versatile and modular quasi optics-based 200GHz dual dynamic nuclear polarization and electron paramagnetic resonance instrument.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Article
- Low-temperature dynamic nuclear polarization with helium-cooled samples and nitrogen-driven magic-angle spinning.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Article
- Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization.Journal of the American Chemical Society · 2015Article
- Perturbation of nuclear spin polarizations in solid state NMR of nitroxide-doped samples by magic-angle spinning without microwaves.The Journal of chemical physics · 2014Article
- Micron-scale magnetic resonance imaging based on low temperatures and dynamic nuclear polarization.Progress in nuclear magnetic resonance spectroscopyReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We describe the synthesis of new nitroxide-based biradical, triradical, and tetraradical compounds and the evaluation of their performance as paramagnetic dopants in dynamic nuclear polarization (DNP) experiments in solid state nuclear magnetic resonance (NMR) spectroscopy with magic-angle spinning (MAS). Under our experimental conditions, which include temperatures in the 25-30 K range, a 9.4 T magnetic field, MAS frequencies of 6.2-6.8 kHz, and microwave irradiation at 264.0 GHz from a 800 mW extended interaction oscillator source, the most effective compounds are triradicals that are related to the previously-described compound DOTOPA-TEMPO (see Thurber et al., 2010), but have improved solubility in glycerol/water solvent near neutral pH. Using these compounds at 30 mM total nitroxide concentration, we observe DNP enhancement factors of 92-128 for cross-polarized (13)C NMR signals from (15)N,(13)C-labeled melittin in partially protonated glycerol/water, and build-up times of 2.6-3.8s for (1)H spin polarizations. Net sensitivity enhancements with biradical and tetraradical dopants, taking into account absolute (13)C NMR signal amplitudes and build-up times, are approximately 2-4 times lower than with the best triradicals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.