Evidence map›Paper›PMID 24887159›Full record

ArticleEpidemiology (Cambridge, Mass.)2014

On the causal interpretation of race in regressions adjusting for confounding and mediating variables.

Tyler J VanderWeele, Whitney R Robinson

Abstract read
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 284 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Trial
  4. Trial
  5. Racial inequities in severe maternal morbidity among Black and White people in Canada: a population-based cohort study, 2012 to 2023.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
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  16. Maternal and neonatal health in Canada's Black communities: A scoping review of epidemiologic studies.Canadian journal of public health = Revue canadienne de sante publique · 2026
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  17. Review
  18. Need-standardised comparisons are required before inferring sex and gender bias in major trauma care.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026
    Article
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  20. Review

224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Tyler J VanderWeeleFrom the aDepartments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA; and bDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Whitney R Robinson

Funding

Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Statistical Methods for the Spatio-Temporal Assessment of Social Disparities in CancerP01CA134294 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LIN, XIHONG · 2008 to 2017
$6.8M
Theory and methods for sufficient cause interactionsR01ES017876 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI VANDERWEELE, TYLER · 2010 to 2014
$1.2M
Racial disparities in cancer outcomes: quantifying modifiable mechanismsK01CA172717 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBINSON, WHITNEY RAGAN · 2012 to 2016
$639k
Theory and methods for interactionR56ES017876 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI TCHETGEN TCHETGEN, ERIC JOEL, VANDERWEELE, TYLER · 2016 to 2016
$150k
NCI NIH HHS K01 CA172717NCI NIH HHS P01 CA134294NCI NIH HHS R35 CA197449NICHD NIH HHS P01 HD031921NICHD NIH HHS P2C HD050924NIEHS NIH HHS ES017876NIEHS NIH HHS R01 ES017876NIEHS NIH HHS R56 ES017876
6 · The paper itself

Abstract

We consider several possible interpretations of the "effect of race" when regressions are run with race as an exposure variable, controlling also for various confounding and mediating variables. When adjustment is made for socioeconomic status early in a person's life, we discuss under what contexts the regression coefficients for race can be interpreted as corresponding to the extent to which a racial inequality would remain if various socioeconomic distributions early in life across racial groups could be equalized. When adjustment is also made for adult socioeconomic status, we note how the overall racial inequality can be decomposed into the portion that would be eliminated by equalizing adult socioeconomic status across racial groups and the portion of the inequality that would remain even if adult socioeconomic status across racial groups were equalized. We also discuss a stronger interpretation of the effect of race (stronger in terms of assumptions) involving the joint effects of race-associated physical phenotype (eg, skin color), parental physical phenotype, genetic background, and cultural context when such variables are thought to be hypothetically manipulable and if adequate control for confounding were possible. We discuss some of the challenges with such an interpretation. Further discussion is given as to how the use of selected populations in examining racial disparities can additionally complicate the interpretation of the effects.

Indexed as

CausalityBlack PeopleConfounding Factors, EpidemiologicEthnicityHumansPhenotypeRacial GroupsRegression AnalysisSocioeconomic FactorsWhite People

Identifiers

PMID24887159
PMCPMC4125322

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.