Observational studyCritical care (London, England)2014
Early fluid loading in acute respiratory distress syndrome with septic shock deteriorates lung aeration without impairing arterial oxygenation: a lung ultrasound observational study.
Observational study in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 136 citations in OpenAlex.
- Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial.Critical care (London, England) · 2024Trial
- International evidence-based recommendations for point-of-care lung ultrasound : 2025 focused update of the 2012 recommendations.Intensive care medicine · 2026Article
- Measuring and managing pulmonary edema in ARDS: a narrative review.Critical care (London, England) · 2026Review
- Early lung ultrasound score changes predict the failure of non-invasive respiratory supports in acute hypoxemic patients: a multicenter prospective observational study.Critical care (London, England) · 2026Observational
- Bedside lung ultrasound versus chest CT in critically ill patients: a cross-sectional diagnostic accuracy study.Frontiers in medicine · 2026Article
- Transesophageal lung ultrasound score is associated with arterial oxygenation and clinical outcomes in mechanically ventilated critically ill patients.Intensive care medicine experimental · 2025Article
- ESICM-ESPNIC international expert consensus on quantitative lung ultrasound in intensive care.Intensive care medicine · 2025Article
- Lung Ultrasound in Critical Care: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Relationship between lung consolidation size measured by ultrasound and outcome in ICU patients with respiratory failure.BMC pulmonary medicine · 2025Observational
- Correlation of sonographic and radiographic scores of lung edema and metrics of shunt, dead space, and respiratory mechanics in invasively ventilated patients.Critical care science · 2025Observational
- Nuts and bolts of lung ultrasound: utility, scanning techniques, protocols, and findings in common pathologies.Critical care (London, England) · 2024Review
- Establishment of seven lung ultrasound phenotypes: a retrospective observational study of an LUS registry.BMC pulmonary medicine · 2024Observational
- Lung ultrasound diagnosis of pulmonary edema resulting from excessive fluid absorption during hysteroscopic myomectomy: a case report.BMC anesthesiology · 2024Article
- Impact of different intravenous bolus rates on fluid and electrolyte balance and mortality in critically ill patients.World journal of critical care medicine · 2024Review
- Predicting Successful Weaning through Sonographic Measurement of the Rapid Shallow Breathing Index.Journal of clinical medicine · 2024Article
- Article
- Evaluation of a Lung Ultrasound Score in Hospitalized Adult Patients with COVID-19 in Barcelona, Spain.Journal of clinical medicine · 2024Article
- Advanced Respiratory Monitoring during Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2024Review
- Fluid Management in Acute Respiratory Failure.Critical care clinics · 2024Review
- Lung Imaging and Artificial Intelligence in ARDS.Journal of clinical medicine · 2024Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe study was designed to assess the impact of fluid loading on lung aeration, oxygenation and hemodynamics in patients with septic shock and acute respiratory distress syndrome (ARDS).
methodsDuring a 1-year period, a prospective observational study was performed in 32 patients with septic shock and ARDS. Cardiorespiratory parameters were measured using Swan Ganz (n = 29) or PiCCO catheters (n = 3). Lung aeration and regional pulmonary blood flows were measured using bedside transthoracic ultrasound. Measurements were performed before (T0), at the end of volume expansion (T1) and 40 minutes later (T2), consisting of 1-L of saline over 30 minutes during the first 48 h following onset of septic shock and ARDS.
resultsLung ultrasound score increased by 23% at T2, from 13 at baseline to 16 (P < 0.001). Cardiac index and cardiac filling pressures increased significantly at T1 (P < 0.001) and returned to control values at T2. The increase in lung ultrasound score was statistically correlated with fluid loading-induced increase in cardiac index and was not associated with increase in pulmonary shunt or regional pulmonary blood flow. At T1, PaO2/FiO2 significantly increased (P < 0.005) from 144 (123 to 198) to 165 (128 to 226) and returned to control values at T2, whereas lung ultrasound score continued to increase.
conclusionsEarly fluid loading transitorily improves hemodynamics and oxygenation and worsens lung aeration. Aeration changes can be detected at the bedside by transthoracic lung ultrasound, which may serve as a safeguard against excessive fluid loading.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.