ArticlePloS one2014
Trajectories in glycemic control over time are associated with cognitive performance in elderly subjects with type 2 diabetes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review.Aging and disease · 2025Pooled it
- Longitudinal trends in HbADiabetes/metabolism research and reviews · 2018Pooled it
- Metabolic and Immune System Dysregulation: Unraveling the Connections between Alzheimer's Disease, Diabetes, Inflammatory Bowel Diseases, and Rheumatoid Arthritis.Journal of clinical medicine · 2024Review
- SGLT2 inhibitors: a novel therapy for cognitive impairment via multifaceted effects on the nervous system.Translational neurodegeneration · 2024Review
- Data-Driven Identification of Long-Term Glycemia Clusters and Their Individualized Predictors in Finnish Patients with Type 2 Diabetes.Clinical epidemiology · 2023Article
- Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline.International journal of molecular sciences · 2022Review
- Article
- The Relationship Between Glucose Control and Cognitive Function in People With Diabetes After a Lacunar Stroke.The Journal of clinical endocrinology and metabolism · 2021Article
- Population segmentation of type 2 diabetes mellitus patients and its clinical applications - a scoping review.BMC medical research methodology · 2021Article
- Aberrant Brain Spontaneous Activity and Synchronization in Type 2 Diabetes Mellitus Subjects Without Mild Cognitive Impairment.Frontiers in neuroscience · 2021Article
- Barriers to Diabetes Self-Management in a Subset of New Zealand Adults with Type 2 Diabetes and Poor Glycaemic Control.Journal of diabetes research · 2021Article
- Glucose-Dementia Association Is Consistent Over Blood Pressure/Antihypertensive Groups.Journal of Alzheimer's disease : JAD · 2021Article
- Long-term trajectories of BMI predict carotid stiffness and plaque volume in type 2 diabetes older adults: a cohort study.Cardiovascular diabetology · 2020Article
- Trajectories of glycaemia following acute pancreatitis: a prospective longitudinal cohort study with 24 months follow-up.Journal of gastroenterology · 2020Article
- Diabetes-Related Topics in an Online Forum for Caregivers of Individuals Living With Alzheimer Disease and Related Dementias: Qualitative Inquiry.Journal of medical Internet research · 2020Article
- Randomized Clinical Trial Examining the Impact ofNeuropsychiatric disease and treatment · 2020Article
- Time-dependent impairments in learning and memory in Streptozotocin-induced hyperglycemic rats.Metabolic brain disease · 2019Article
- Cognitive Frailty in Older People with Type 2 Diabetes Mellitus: the Central Role of Hypoglycaemia and the Need for Prevention.Current diabetes reports · 2019Review
- A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adults.Contemporary clinical trials communications · 2018Article
- Identifying Latent Subgroups of High-Risk Patients Using Risk Score Trajectories.Journal of general internal medicine · 2018Observational
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo study the relationships of long-term trajectories of glycemic control with cognitive performance in cognitively normal elderly with type 2 diabetes (T2D).
methodsSubjects (n = 835) pertain to a diabetes registry (DR) established in 1998 with an average of 18 HbA1c measurements per subject, permitting identification of distinctive trajectory groups of HbA1c and examining their association with cognitive function in five domains: episodic memory, semantic categorization, attention/working memory, executive function, and overall cognition. Analyses of covariance compared cognitive function among the trajectory groups adjusting for sociodemographic, cardiovascular, diabetes-related covariates and depression.
resultsSubjects averaged 72.8 years of age. Six trajectories of HbA1c were identified, characterized by HbA1c level at entry into the DR (Higher/Lower), and trend over time (Stable/Decreasing/Increasing). Both groups with a trajectory of decreasing HbA1c levels had high HbA1c levels at entry into the DR (9.2%, 10.7%), and high, though decreasing, HbA1c levels over time. They had the worst cognitive performance, particularly in overall cognition (p<0.02) and semantic categorization (p<0.01), followed by that of subjects whose HbA1c at entry into the DR was relatively high (7.2%, 7.8%) and increased over time. Subjects with stable HbA1c over time had the lowest HbA1c levels at entry (6.0%, 6.8%) and performed best in cognitive tests.
conclusionGlycemic control trajectories, which better reflect chronicity of T2D than a single HbA1c measurement, predict cognitive performance. A trajectory of stable HbA1c levels over time is associated with better cognitive function.
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