Evidence map›Paper›PMID 24887087›Full record

ArticlePloS one2014

The effects of exercise on synaptic stripping require androgen receptor signaling.

Caiyue Liu, Patricia J Ward, Arthur W English

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Caiyue LiuDepartment of Plastic and Reconstructive Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Patricia J WardDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Arthur W EnglishDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Emory University · USSecond Military Medical University · CN

Funding

SPINAL CIRCUITS &THE MUSCULOSKELETAL SYSTEMP01HD032571 · NICHD · EMORY UNIVERSITY · PI GOOLSBY, WILLIAM · 1995 to 2016
$16.2M
Exercise, neurotrophins, and axon regeneration in the PNSR01NS057190 · NINDS · EMORY UNIVERSITY · PI ENGLISH, ARTHUR W. · 2007 to 2016
$3.3M
NICHD NIH HHS HD032571NICHD NIH HHS P01 HD032571NINDS NIH HHS NS057190NINDS NIH HHS R01 NS057190
6 · The paper itself

Abstract

Following peripheral nerve injury, synapses are withdrawn from axotomized motoneurons. Moderate daily treadmill exercise, which promotes axon regeneration of cut peripheral nerves, also influences this synaptic stripping. Different exercise protocols are required to promote axon regeneration in male and female animals, but the sex requirements for an effect of exercise on synaptic stripping are unknown. In male and female C57BL/6 mice, the sciatic nerve was transected in the mid-thigh. Mice were then exercised five days per week for two weeks, beginning on the third post-transection day. Half of the exercised mice were trained by walking slowly (10 M/min) on a level treadmill for one hour per day (continuous training). Other mice were interval trained; four short (two min) sprints at 20 M/min separated by five minute rest periods. A third group was untrained. The extent of synaptic contacts made by structures immunoreactive to vesicular glutamate transporter 1 and glutamic acid decarboxylase 67 onto axotomized motoneurons was studied in confocal images of retrogradely labeled cells. Both types of presumed synaptic contacts were reduced markedly in unexercised mice following nerve transection, relative to intact mice. No significant reduction was found in continuous trained males or interval trained females. Reductions in these contacts in interval trained males and continuous trained females were identical to that observed in untrained mice. Treatments with the anti-androgen, flutamide, blocked the effect of sex-appropriate exercise on synaptic contacts in both males and females. Moderate daily exercise has a potent effect on synaptic inputs to axotomized motoneurons. Successful effects of exercise have different requirements in males and females, but require androgen receptor signaling in both sexes.

Indexed as

Physical Conditioning, AnimalSignal TransductionAnimalsFemaleMaleMiceMice, Inbred C57BLReceptors, AndrogenSciatic NerveSynapsesReceptors, Androgen

Identifiers

PMID24887087
PMCPMC4041790
OpenAlexW2060763451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.