Evidence map›Paper›PMID 24886865›Full record

ReviewMarine drugs2014

Quorum quenching agents: resources for antivirulence therapy.

Kaihao Tang, Xiao-Hua Zhang

Abstract readReview
In one paragraph

Review in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Towards EffectiveInternational journal of molecular sciences · 2025
    Review
  6. Repurposing Diflunisal as an Antivirulence Agent AgainstInfectious microbes & diseases · 2025
    Article
  7. RmmLII, a novel marine-derivedFrontiers in microbiology · 2025
    Article
  8. An insight on the powerful of bacterial quorum sensing inhibition.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Review
  9. Review
  10. Epigallocatechin gallate protects mice fromFrontiers in cellular and infection microbiology · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Life (Basel, Switzerland) · 2022
    Article
  18. Article
  19. A Brominated Furanone InhibitsBiomedicines · 2022
    Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kaihao TangCollege of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. kaihao.tang@gmail.com.
Xiao-Hua ZhangCollege of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. xhzhang@ouc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The continuing emergence of antibiotic-resistant pathogens is a concern to human health and highlights the urgent need for the development of alternative therapeutic strategies. Quorum sensing (QS) regulates virulence in many bacterial pathogens, and thus, is a promising target for antivirulence therapy which may inhibit virulence instead of cell growth and division. This means that there is little selective pressure for the evolution of resistance. Many natural quorum quenching (QQ) agents have been identified. Moreover, it has been shown that many microorganisms are capable of producing small molecular QS inhibitors and/or macromolecular QQ enzymes, which could be regarded as a strategy for bacteria to gain benefits in competitive environments. More than 30 species of marine QQ bacteria have been identified thus far, but only a few of them have been intensively studied. Recent studies indicate that an enormous number of QQ microorganisms are undiscovered in the highly diverse marine environments, and these marine microorganism-derived QQ agents may be valuable resources for antivirulence therapy.

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaBacterial InfectionsDrug Resistance, BacterialHumansOceans and SeasQuorum SensingAnti-Bacterial Agents

Identifiers

PMID24886865
PMCPMC4071575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.