ArticleJAMA neurology2014
Secondary prevention trials in Alzheimer disease: the challenge of identifying a meaningful end point.
Article in JAMA neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials.Journal of neurology, neurosurgery, and psychiatry · 2020Pooled it
- Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE).JAMA neurology · 2017Trial
- Trial
- Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled Trial.PloS one · 2015Trial
- Association of Stages of Objective Memory Impairment With Incident Symptomatic Cognitive Impairment in Cognitively Normal Individuals.Neurology · 2023Article
- Plasma amyloid-β42/40 and apolipoprotein E for amyloid PET pre-screening in secondary prevention trials of Alzheimer's disease.Brain communications · 2023Article
- Composite cognitive and functional measures for early stage Alzheimer's disease trials.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Cognitive composite score association with Alzheimer's disease plaque and tangle pathology.Alzheimer's research & therapy · 2018Article
- Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Review
- Risk of dementia and death in the long-term follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Article
- Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016Article
- Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.Cell metabolism · 2015Review
- Prevention studies in Alzheimer's disease: progress towards the development of new therapeutics.CNS drugs · 2015Article
- Subtle Cognitive Decline and Biomarker Staging in Preclinical Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2015Article
- Before it is too late: professional responsibilities in late-onset Alzheimer's research and pre-symptomatic prediction.Frontiers in human neuroscience · 2014Article
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Authors and funding
1 author.
Funding
Abstract
PubMed holds no abstract for this paper.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.